Respiratory challenges and ventilatory management in different types of acute brain-injured patients – Critical Care  

The post Review | Respiratory challenges and ventilatory management in different types of acute brain-injured patients appeared first on Links Medicus.

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis – Cochrane Library  

The post SR | Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis appeared first on Links Medicus.

HES and EGPA: Two Sides of the Same Coin – Mayo Clinic Proceedings  

The post Review | Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA): two sides of the same coin appeared first on Links Medicus.

Post-COVID Conditions – Mayo Clinic Proceedings  

The post Review | Post-COVID Conditions appeared first on Links Medicus.

Efficacy of varenicline versus bupropion for smoking cessation: A systematic review and meta-analysis of randomized controlled trials – Indian Journal of Psychiatry  

The post M-A | Efficacy of varenicline versus bupropion for smoking cessation appeared first on Links Medicus.

Study Design and Population: This prospective cohort study analyzed medical records and patient interactions from July 2017 to March 2020 across 48 Michigan hospitals. A total of 17,290 adults admitted for general care were retrospectively assessed for community-acquired pneumonia (CAP) treatment, focusing on those who received antibiotics within the first two days of hospitalization.   […]

The post Cohort Study: Inappropriate pneumonia diagnoses and associated risks in 17,290 hospitalized adults appeared first on Links Medicus.

The FDA has granted approval for Zevtera (ceftobiprole medocaril sodium), an antibiotic formulated for injection, targeting three key bacterial infections. This includes treatment for adults with Staphylococcus aureus bloodstream infections (SAB) with or without right-sided infective endocarditis, acute bacterial skin and skin structure infections (ABSSSI), and community-acquired bacterial pneumonia (CABP) in both adults and pediatric […]

The post FDA approves antibiotic Zevtera (ceftobiprole medocaril sodium) for three indications appeared first on Links Medicus.

Study Design and Population: This phase 2–3 randomized clinical trial investigated the efficacy of nirmatrelvir in combination with ritonavir for treating mild-to-moderate Covid-19 in adults. Participants, both vaccinated and unvaccinated, were enrolled based on their risk factors for severe Covid-19. The study included 1296 adults who had confirmed Covid-19 with symptom onset within the past […]

The post RCT: Lack of significant effect of Paxlovid (nirmatrelvir–ritonavir) on symptom alleviation in Covid-19 appeared first on Links Medicus.

This randomized, double-blind, placebo-controlled trial investigated the effectiveness of adjuvant oral prednisone in enhancing lung function recovery in patients with cystic fibrosis (CF) experiencing pulmonary exacerbations (PExs) unresponsive to initial intravenous (IV) antibiotic treatment. The study involved 173 participants, with 76 not achieving more than 90% of their baseline forced expiratory volume in one second […]

The post RCT: No significant benefit of adjuvant prednisone for patients with cystic fibrosis with exacerbations unresponsive to antibiotics – Eur Respir J appeared first on Links Medicus.

Study Design and Population: The ORCA-V1 study was a double-blind, placebo-controlled randomized clinical trial conducted across five US clinical sites from July 2022 to February 2023. It enrolled 160 adults who used nicotine e-cigarettes daily and expressed a desire to quit, but were not current cigarette smokers. Participants were predominantly middle-aged (mean age 33.6 years), […]

The post RCT: Cytisinicline shows promising results in enhancing vaping cessation among adults – JAMA Intern Med appeared first on Links Medicus.