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RCT: Telehealth-Delivered Early Palliative Care Equivalent to In-Person Care in Advanced Lung Cancer

Background: Patients with advanced lung cancer often face a high symptom burden and decreased quality of life (QOL), but access to early palliative care, which can improve these outcomes, remains limited. While telehealth has become increasingly utilized due to the COVID-19 pandemic, it is unclear whether virtual palliative care is as effective as in-person care. […]

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Summary: Perioperative Management of Patients Taking Direct Oral Anticoagulants

Direct oral anticoagulants (DOACs)—including apixaban, rivaroxaban, edoxaban, and dabigatran—are increasingly used for stroke prevention in atrial fibrillation and for treating venous thromboembolism. Effective perioperative management of DOACs is essential to minimize bleeding and thromboembolic risks during surgical and nonsurgical procedures. Below are practical recommendations focused on the perioperative management of patients taking DOACs, based on […]

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Summary: Community-Acquired Pneumonia

Introduction Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality, accounting for approximately 1.4 million emergency department visits, 740,000 hospitalizations, and 41,000 deaths annually in the United States. Effective management of CAP requires prompt and accurate diagnosis, appropriate antimicrobial therapy, and consideration of adjunctive treatments. This summary highlights key practice points from a […]

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RCT: Twice-Yearly Depemokimab Reduced Exacerbations in Severe Eosinophilic Asthma

Background: Severe asthma with an eosinophilic phenotype often leads to frequent exacerbations despite treatment with medium- or high-dose inhaled glucocorticoids and additional controllers. Interleukin-5 is pivotal in eosinophil growth and survival, contributing to airway inflammation. Existing biologic therapies targeting interleukin-5 require frequent dosing intervals. Depemokimab is an ultra-long-acting anti–interleukin-5 biologic with enhanced binding affinity, potentially […]

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RCT: High-Intensity NPPV Reduced Criteria for Intubation in Acute COPD Exacerbations

Background: Acute exacerbations of chronic obstructive pulmonary disease (COPD) often lead to hypercapnic respiratory failure requiring ventilatory support. Noninvasive positive pressure ventilation (NPPV) is standard care, commonly delivered at low intensity with lower inspiratory pressures. However, approximately 15% of patients still require endotracheal intubation despite low-intensity NPPV. High-intensity NPPV, using higher inspiratory pressures to achieve […]

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M-A | Routine anaerobic coverage for aspiration pneumonia: limited evidence of benefit

Summary: Treating aspiration pneumonia with antibiotics that cover anaerobic bacteria has become common practice in many services, but recent studies suggest that this may not necessarily improve prognosis. Out of 2523 publications, this systematic review and meta-analysis only included one randomized control trial and two observational studies. The study found no clear benefit of anaerobic […]

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Review | Reducing errors resulting from commonly missed chest radiography findings

Reducing Errors Resulting From Commonly Missed Chest Radiography Findings – CHEST (free for a limited period) See also: Commonly Missed Findings on Chest Radiographs: Causes and Consequences – CHEST (free for a limited period)  

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Review | Commonly missed findings on chest radiographs: causes and consequences

Commonly Missed Findings on Chest Radiographs: Causes and Consequences – CHEST (free for a limited period) See also: Reducing Errors Resulting From Commonly Missed Chest Radiography Findings – CHEST (free for a limited period)  

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Review | Guideline-based management of acute respiratory failure and acute respiratory distress syndrome

Guideline-based management of acute respiratory failure and acute respiratory distress syndrome – Journal of Intensive Care  

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Review | Role of precision medicine in obstructive sleep apnea

Role of precision medicine in obstructive sleep apnoea – BMJ Medicine   Commentary on Twitter #Review: Role of precision medicine in obstructive sleep #apnoea ▶️https://t.co/OnxOHR2F6T#BMJMedicine pic.twitter.com/GUT3dKkfvL — BMJMedicine (@BMJMedicine) March 9, 2023  

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