RCT | Sotatercept improves exercise capacity in patients with pulmonary arterial hypertension
Summary: This multicenter, double-blind randomized trial involved 323 adults with Pulmonary Arterial Hypertension (PAH) who were randomized to receive either subcutaneous sotatercept or placebo every three weeks for 24 weeks. The primary endpoint was the change from baseline in the 6-minute walk distance. Sotatercept demonstrated a greater improvement in exercise capacity compared to placebo and […]
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M-A | Pretest probability assessment and D-Dimer are preferred for the initial evaluation of suspected PE in pregnant women
Noninvasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data – Journal of Thrombosis and Haemostasis
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ACCP Guidelines | Respiratory management of patients with neuromuscular weakness
Respiratory Management of Patients with Neuromuscular Weakness: An American College of Chest Physicians Clinical Practice Guideline and Expert Panel Report – CHEST News Release: Clinical practice guideline on respiratory management of patients with neuromuscular weakness – American College of Chest Physicians
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Cohort Study | Leukotriene-receptor antagonist use during pregnancy not linked to neuropsychiatric events in offspring
Use of Leukotriene-Receptor Antagonists During Pregnancy and Risk of Neuropsychiatric Events in Offspring – JAMA Network Open Commentary: In utero exposure to asthma medication not tied to risks of neurodevelopmental disorders – MDedge
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Cohort Study | COVID-19 outpatients mostly at low risk for VTE, but age, being male, and obesity are risk factors
Summary: The article discusses a cohort study that aimed to assess the risk of venous thromboembolism (VTE) among outpatients with COVID-19 and identify independent predictors of VTE. The study used data from two integrated healthcare delivery systems in California and included 398.530 nonhospitalized adults aged 18 years or older with COVID-19 diagnosed between January 1, […]
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AHA Scientific Statement | Evaluation and management of pulmonary hypertension in noncardiac surgery
Evaluation and Management of Pulmonary Hypertension in Noncardiac Surgery: A Scientific Statement From the American Heart Association – Circulation Top Things to Know: Evaluation and Management of Pulmonary HTN in Non-Cardiac Surgery – American Heart Association Commentary: Pulmonary Hypertension in Non-Cardiac Surgery – a mandate for the multidisciplinary team! – American Heart Association
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Brief Review | High-risk pulmonary embolism in the ICU
High-risk pulmonary embolism in the intensive care unit – Intensive Care Medicine (free for a limited period)
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Perspective | Trials on oxygen targets in the critically ill patients: do they change our knowledge and practice?
Trials on oxygen targets in the critically ill patients: do they change our knowledge and practice? – Intensive Care Medicine (if the link is paywalled, try this one) Commentary on Twitter ? Trials on liberal/conservative O2 targets in #ICU: conflicting results! Many studies in progress. Waiting for evidence, consider O2 as powerful drug to […]
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Cohort Study | Early childhood respiratory infections linked to increased risk of premature respiratory disease mortality in adulthood
Summary: The study aimed to determine the link between lower respiratory tract infections (LRTIs) in early childhood and premature adult death from respiratory disease. The study used data from a nationally representative cohort recruited at birth in Great Britain in 1946 and followed participants across eight decades. After adjusting for multiple markers of childhood social […]
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Review | Enhanced recovery after surgery and chest tube management
Enhanced recovery after surgery and chest tube management – Journal of Thoracic Disease Related: Summary of best evidence for enhanced recovery after surgery for patients undergoing lung cancer operations – Asia-Pacific Journal of Oncology Nursing Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS®) Society and the European Society […]
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