[Preprint] Breakthrough SARS-CoV-2 infections in 620,000 U.S. Veterans, February 1, 2021 to August 13, 2021 – “Vaccine protection declined by mid-August 2021, decreasing from 91.9% in March to 53.9%”.
Breakthrough SARS-CoV-2 infections in 620,000 U.S. Veterans, February 1, 2021 to August 13, 2021 – medRxiv Related: Observational study in Qatar showed the effectiveness of Pfizer vaccine against any SARS-CoV-2 infection dropped to 20% in months 5 through 7 after the second dose, but effectiveness against severe Covid-19 remained high. Cohort study: Pfizer vaccine effectiveness […]
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J&J COVID-19 Vaccine: FDA recommends booster shot for all adults aged 18 and older at least two months following initial vaccination with the single-shot vaccine.
News release: Johnson & Johnson COVID-19 Vaccine Booster Shot Unanimously Recommended for Emergency Use Authorization by U.S. FDA Advisory Committee Commentaries: FDA panel endorses booster shot for J&J COVID-19 vaccine – Associated Press The Johnson & Johnson one-dose vaccine offers good protection now. A booster shot will maximize that, experts say – CNN FDA advisers […]
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RCT supports the use of therapeutic heparin in moderately ill patients admitted to the hospital with Covid-19.
Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial – The BMJ Commentary: High-dose of readily available blood thinner reduces risk of death for moderately ill COVID-19 patients – St. Michael’s Hospital Related studies (some […]
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WHO Report: Tuberculosis deaths rise for the first time in more than a decade due to the COVID-19 pandemic.
Tuberculosis deaths rise for the first time in more than a decade due to the COVID-19 pandemic – World Health Organization Report: Global tuberculosis report 2021 Commentary: Tuberculosis deaths rise for 1st time in years, due to COVID – Associated Press Commentary on Twitter (thread – click for more) ? WHO's Global TB Report […]
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Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.
Maternal Outcomes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Vaccinated Compared With Unvaccinated Pregnant Patients – Obstetrics & Gynecology Related: Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy. Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy. 5 Crucial Things to Know […]
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Perspective | Trying to Block SARS-CoV-2 Transmission With Intranasal Vaccines.
Trying to Block SARS-CoV-2 Transmission With Intranasal Vaccines – JAMA
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Statins linked to reduced risk of death from COVID-19 in major population study – “Randomized studies will be needed to ascertain whether there is a causal relationship, note the researchers”.
News release: Statins linked to reduced risk of death from COVID-19 in major population study – Karolinska Institutet Original study: HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study – PLOS Medicine Commentaries: Expert reaction to study looking at statins and risk of death from COVID-19 – Science Media Centre People […]
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Study evaluated several heterologous SARS-CoV-2 vaccine regimens; no efficacy data but there was increased antibody production on study days 15 and 29 after booster shots from Moderna and Pfizer.
Heterologous SARS-CoV-2 Booster Vaccinations: Preliminary Report – medRxiv Commentary: Study: Mixing and Matching COVID-19 Booster Shots Is Effective, Safe – U.S. News Commentary on Twitter So yes, mRNA vaccines are great at generating antibodies but what does that mean? Where is the efficacy data? How come JnJ gets really great efficacy at preventing symptomatic […]
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Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.
Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review – JAMA Network Open Commentaries: Most COVID-19 survivors have symptoms 6 months on, review finds – CIDRAP Expert reaction to systematic review on rates of postacute sequelae of SARS-CoV-2 infection (PASC) – Science Media Centre How many people get ‘long COVID’? More […]
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[Preprint] In RCT with 29,949 participants, the Novavax vaccine demonstrated high overall efficacy (>90%) for the prevention of Covid-19, and all moderate-to-severe cases occurred in placebo recipients.
Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico – medRxiv Commentary: Novel vaccine demonstrates high efficacy for prevention of COVID-19 – News Medical Related: RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths. Opinion | The mRNA vaccines are extraordinary, but Novavax […]
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