RCT: Among patients hospitalized with COVID-19 at increased risk for venous thromboembolism, post-discharge thromboprophylaxis with Rivaroxaban for 35 days may improve outcomes.
Rivaroxaban versus no anticoagulation for post-discharge thromboprophylaxis after hospitalisation for COVID-19 (MICHELLE): an open-label, multicentre, randomised, controlled trial – The Lancet Invited commentary: Anticoagulation in COVID-19 – The Lancet Commentary on Twitter NEW: The role of extended thromboprophylaxis in patients hospitalised with COVID-19 at risk for thrombotic events after discharge – findings from MICHELLE […]
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RCT: Molnupiravir reduced the risk of hospitalization or death in at-risk (i.e., obesity, over 60 years, etc.) unvaccinated adults with Covid-19.
Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients – New England Journal of Medicine Related: Merck’s COVID pill loses its lustre: what that means for the pandemic – Nature (several articles on the subject)
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Randomized trial with nearly 30.000 individuals showed Novavax vaccine was safe and had an overall efficacy of 90.4% against symptomatic infections.
Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico – New England Journal of Medicine Commentaries: Novavax COVID vaccine shows 90.4% efficacy against infection – CIDRAP Novavax COVID-19 vaccine found to be safe and effective – University of Maryland School of Medicine Related: [Preprint] In RCT with 29,949 participants, the Novavax […]
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WHO issues interim recommendations for heterologous COVID-19 vaccine schedules.
Interim recommendations for heterologous COVID-19 vaccine schedules – World Health Organization Commentary: Coronavirus: WHO gives the nod for mix-and-match vaccine schedules – South China Morning Post
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Merck’s COVID pill loses its luster: what that means for the pandemic – “Molnupiravir was initially heralded by public-health officials as a game-changer for COVID-19, but full clinical-trial data showed lower-than-expected efficacy”.
Merck’s COVID pill loses its lustre: what that means for the pandemic – Nature Related: FDA panel narrowly recommends authorization of first antiviral pill to treat COVID. [Press release – not published yet] Merck’s new Covid-19 pill Molnupiravir updated data shows reduced efficacy (30%) for preventing hospitalization and death compared to initial results (50%). Absolute […]
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[Not published yet] Initial data from South Africa showed vaccine protection vs. Omicron infection may drop to 30% but does cut severe disease.
Vaccine protection vs. omicron infection may drop to 30% but does cut severe disease – NPR See also: South Africa Omicron study finds drop in vaccine protection, fewer hospitalized – CIDRAP
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Rapidly spreading Omicron is now in 77 countries and WHO warns against assuming its effects are mild.
Rapidly Spreading Omicron is Now in 77 Countries and WHO Warns Against Assuming its Effects are Mild – Health Policy Watch
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Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.
Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection – Nature Medicine News release: COVID-19 infection, more likely than vaccines, to cause rare cardiovascular complications – University of Oxford Commentaries on Twitter Hugely important work from @JuliaHCox and colleagues: In people <40, Pfizer carries a much lower risk of […]
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[Press release – not published yet] Pfizer’s Covid pill remains 89% effective for reducing the risk of hospitalization or death in final analysis.
News release: Pfizer announces additional phase 2/3 study results confirming robust efficacy of novel Covid-19 oral antiviral treatment candidate in reducing risk of hospitalization or death Commentaries: Pfizer’s Covid pill remains 89% effective in final analysis, company says – STAT Pfizer confirms COVID pill’s results, potency versus omicron – Associated Press Related: 8 lingering questions […]
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M-A: Global percentage of asymptomatic SARS-CoV-2 infections around 40%.
Global Percentage of Asymptomatic SARS-CoV-2 Infections Among the Tested Population and Individuals With Confirmed COVID-19 Diagnosis: A Systematic Review and Meta-analysis – JAMA Network Open Commentary: ~40 Percent With Confirmed COVID-19 Are Asymptomatic – HealthDay
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