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RCT | Metformin, Ivermectin, and Fluvoxamine are not beneficial for obese outpatients with Covid-19.

Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19 – New England Journal of Medicine Editorial: Time to Stop Using Ineffective Covid-19 Drugs – New England Journal of Medicine   Commentary on Twitter In this trial involving overweight or obese outpatients with Covid-19, investigators found that none of three repurposed drugs (metformin, ivermectin, and fluvoxamine) […]

The post RCT | Metformin, Ivermectin, and Fluvoxamine are not beneficial for obese outpatients with Covid-19. appeared first on Links Medicus.

NICE Guideline | Pneumonia in adults: diagnosis and management.

Pneumonia in adults: diagnosis and management – National Institute for Health and Care Excellence Related Guidelines: Pneumonia (community-acquired): antimicrobial prescribing Pneumonia (hospital-acquired): antimicrobial prescribing Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America – American Journal of Respiratory and Critical […]

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RCT | The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis.

The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text) Commentary: Inhaled hypertonic saline improves structural airway changes in children with cystic fibrosis – Healio (free registration required)  

The post RCT | The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis. appeared first on Links Medicus.

Systematic Review | Antiplatelet agents for the treatment of deep venous thrombosis.

Antiplatelet agents for the treatment of deep venous thrombosis – Cochrane Library Summary: Aspirin and similar drugs for the treatment of deep vein thrombosis (DVT) – Cochrane Library  

The post Systematic Review | Antiplatelet agents for the treatment of deep venous thrombosis. appeared first on Links Medicus.

[PREPRINT] RCT | Inhaled fluticasone not beneficial for outpatients with Covid-19.

Inhaled Fluticasone for Outpatient Treatment of Covid-19: A Decentralized, Placebo-controlled, Randomized, Platform Clinical Trial – medRxiv News Release: Study finds no benefit to taking fluticasone furoate for COVID-19 symptoms – Duke Clinical Research Institute Commentary: Asthma Drug Fluticasone Fails as Potential COVID-19 Treatment – HealthDay  

The post [PREPRINT] RCT | Inhaled fluticasone not beneficial for outpatients with Covid-19. appeared first on Links Medicus.

Retrospective Cohort Study | Effectiveness of a fourth dose of mRNA COVID-19 vaccine against all-cause mortality in long-term care facility residents and in the oldest old.

Effectiveness of a fourth dose of mRNA COVID-19 vaccine against all-cause mortality in long-term care facility residents and in the oldest old: A nationwide, retrospective cohort study in Sweden – The Lancet Regional Health Europe Related: Effectiveness of a fourth dose of covid-19 mRNA vaccine against the omicron variant among long term care residents in […]

The post Retrospective Cohort Study | Effectiveness of a fourth dose of mRNA COVID-19 vaccine against all-cause mortality in long-term care facility residents and in the oldest old. appeared first on Links Medicus.

Guideline Synopsis | Therapy for mild to moderate asthma.

Therapy for Mild to Moderate Asthma – JAMA (free for a limited period) Original Guideline: 2022 GINA Report, Global Strategy for Asthma Management and Prevention Related: Global Initiative for Asthma (GINA) Strategy 2021 – Executive summary and rationale for key changes – European Respiratory Journal  

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M-A | Risk factors for asthma exacerbations during pregnancy.

Risk factors for asthma exacerbations during pregnancy: a systematic review and meta-analysis – European Respiratory Review  

The post M-A | Risk factors for asthma exacerbations during pregnancy. appeared first on Links Medicus.

RCT | Using a smartphone application maintains physical activity following pulmonary rehabilitation in patients with COPD.

Using a smartphone application maintains physical activity following pulmonary rehabilitation in patients with COPD: a randomised controlled trial – Thorax  

The post RCT | Using a smartphone application maintains physical activity following pulmonary rehabilitation in patients with COPD. appeared first on Links Medicus.

RCT | Effect of Nintedanib on progression of systemic sclerosis-associated interstitial lung disease over 100 weeks.

Effect of Nintedanib on Progression of Systemic Sclerosis-Associated Interstitial Lung Disease Over 100 Weeks: Data From a Randomized Controlled Trial – ACR Open Rheumatology Commentary: Durable Efficacy for Drug Preventing Lung Progression in Systemic Sclerosis — One-year results sustained over another 48 weeks – MedPage Today (free registration required)  

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