Cohort Study | Mortality risk in anti-MDA5 dermatomyositis linked to rapid ILD progression and anti-Ro52 antibody levels
Mortality risk in patients with anti-MDA5 dermatomyositis is related to rapidly progressive interstitial lung disease and anti-Ro52 antibody – Arthritis Research & Therapy Commentary on Twitter High mortality risk predictors in patients with anti-MDA5 dermatomyositis include:– rapidly progressive interstitial lung disease– anti-Ro52 antibody– age > 57 years(based on study of 126 MDA-5+ DM pts)https://t.co/JLGIgALUip […]
The post Cohort Study | Mortality risk in anti-MDA5 dermatomyositis linked to rapid ILD progression and anti-Ro52 antibody levels appeared first on Links Medicus.
RCT: Lower oxygenation target improves days alive without life support in severe COVID-19 hypoxemia
Study Design and Population: This multicenter randomized clinical trial investigated the impact of different oxygenation targets on the survival of adult patients with COVID-19 and severe hypoxemia in the ICU. Conducted across 11 European ICUs from August 2020 to March 2023, the study involved 726 patients requiring at least 10 L/min of oxygen or mechanical […]
The post RCT: Lower oxygenation target improves days alive without life support in severe COVID-19 hypoxemia appeared first on Links Medicus.
RCT: Clarithromycin improves early clinical and inflammatory responses in hospitalized community-acquired pneumonia patients
Study Design and Population: The ACCESS trial was a phase 3, prospective, double-blind, randomized controlled trial conducted in 18 Greek hospitals, involving adults hospitalized with community-acquired pneumonia who displayed systemic inflammatory response syndrome, had a Sequential Organ Failure Assessment (SOFA) score of 2 or more, and procalcitonin levels of 0.25 ng/mL or more. Participants were […]
The post RCT: Clarithromycin improves early clinical and inflammatory responses in hospitalized community-acquired pneumonia patients appeared first on Links Medicus.
Nested Case-Control Study: Increased risk of major bleeding in atrial fibrillation patients with concomitant SSRI and oral anticoagulant use
Study Design and Population This nested case-control study investigated the association between the concomitant use of selective serotonin reuptake inhibitors (SSRIs) and oral anticoagulants (OACs) on the risk of major bleeding among patients with atrial fibrillation. Conducted within the UK’s Clinical Practice Research Datalink, the study included 42,190 cases of major bleeding matched to 1,156,641 […]
The post Nested Case-Control Study: Increased risk of major bleeding in atrial fibrillation patients with concomitant SSRI and oral anticoagulant use appeared first on Links Medicus.
Diaphragmatic function in cardiovascular disease: JACC review topic of the week.
Diaphragmatic Function in Cardiovascular Disease: JACC Review Topic of the Week – Journal of the American College of Cardiology
The post Diaphragmatic function in cardiovascular disease: JACC review topic of the week. appeared first on Links Medicus.
RCT | In critically ill patients receiving MV, there was no difference in outcomes between different O2 saturation targets.
Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation – New England Journal of Medicine (link to abstract – $ for full-text) News Release: Study finds that the most common oxygen saturation targets for hospitalized patients appear equally safe and effective – Vanderbilt University Medical Center Related: Effect of Low-Normal vs High-Normal Oxygenation Targets on […]
The post RCT | In critically ill patients receiving MV, there was no difference in outcomes between different O2 saturation targets. appeared first on Links Medicus.
RCT | Ivermectin does not improve time to recovery in outpatients with mild to moderate COVID-19.
Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial – JAMA Commentary: Ivermectin doesn’t speed time to recovery from nonsevere COVID – CIDRAP Commentary on Twitter Study findings do not support the use of #ivermectin in outpatients with mild to moderate #COVID19. […]
The post RCT | Ivermectin does not improve time to recovery in outpatients with mild to moderate COVID-19. appeared first on Links Medicus.
Podcast | Chronic Obstructive Pulmonary Disease (COPD) Update.
#356 Chronic Obstructive Pulmonary Disease (COPD) Update with Dr. Antonio Anzueto – The Curbsiders
The post Podcast | Chronic Obstructive Pulmonary Disease (COPD) Update. appeared first on Links Medicus.
M-A | Higher vs. lower oxygenation strategies in the general intensive care unit population.
Higher versus lower oxygenation strategies in the general intensive care unit population: A systematic review, meta-analysis and meta-regression of randomized controlled trials – Journal of Critical Care Related: Oxygen targets – Intensive Care Medicine (if the link is paywalled, try this one) Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: […]
The post M-A | Higher vs. lower oxygenation strategies in the general intensive care unit population. appeared first on Links Medicus.
RCT | Riociguat improved hemodynamics but increased dropouts in pulmonary hypertension and HFpEF.
Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: the haemoDYNAMIC trial – European Heart Journal Commentary on Twitter Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: results of randomized, double-blind, placebo-controlled, multicentre trial out.https://t.co/FYmorikQR5#HFpEF #HF #cardiotwitter @ESC_Journals @escardio pic.twitter.com/4sSeYt7Adq — EHJ Editor-in-Chief (@ehj_ed) October 7, 2022 Under a […]
The post RCT | Riociguat improved hemodynamics but increased dropouts in pulmonary hypertension and HFpEF. appeared first on Links Medicus.