Moderna COVID-19 vaccine phase III trial results published; it is 94.1% efficacious in preventing symptomatic COVID-19
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine – New England Journal of Medicine Commentaries: Peer-reviewed report on Moderna COVID-19 vaccine publishes – NIH News Releases AND Peer-reviewed data show high protection for leading COVID vaccines – CIDRAP AND The Moderna Vaccine’s Antibodies May Not Last As Long As We Hoped – Forbes Commentary […]
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Debate: Should we delay second vaccine doses to give one dose of the Covid-19 vaccine to more people?
Editorial: U.S. COVID-19 Vaccination Challenges Go Beyond Supply – Annals of Internal Medicine Speed Versus Efficacy: Quantifying Potential Tradeoffs in COVID-19 Vaccine Deployment – Annals of Internal Medicine A Public Health COVID-19 Vaccination Strategy to Maximize the Health Gains for Every Single Vaccine Dose – Annals of Internal Medicine Alternative Dose Allocation Strategies to Increase […]
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New SARS-CoV-2 variants: increased transmissibility likely to cause more deaths and possibly a new wave of the disease
SARS-CoV-2 Variants – World Health Organization Why epidemiologists are so worried about the new Covid-19 variants, in 2 charts – Vox We lost to SARS-CoV-2 in 2020. We can defeat B-117 in 2021 – STAT Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: insights from linking epidemiological and genetic data – Imperial College of London AND […]
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Randomized trial: Neutralizing monoclonal antibody not efficacious among hospitalized patients with covid-19
A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 – New England Journal of Medicine Commentaries: Covid-19: Trial of LY-CoV555 Stopped for Futility – Physician’s Weekly AND Results of NIH-sponsored ACTIV-3 trial published – NIH News Releases AND Bamlanivimab Flops in Hospitalized COVID-19 Patients – MedPage Today (free registration required)
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[Preprint] Randomized trial: Arthritis drugs improve survival in critically ill patients with Covid-19
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – Preliminary report – medRxiv Commentaries: Covid-19: Arthritis drugs improve survival in intensive care patients, shows study – The BMJ AND Arthritis drugs could help save lives of Covid patients, research finds – The Guardian AND Expert comment – Two potentially life-saving drugs for critically ill COVID-19 patients […]
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Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19
Continuation versus discontinuation of renin–angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial – The Lancet Respiratory Medicine Commentary: Commonly used blood pressure medications safe for COVID-19 patients, study finds – University of Pennsylvania School of Medicine NEW Research—renin–angiotensin system inhibitors can be safely continued in patients admitted […]
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CDC Study: Among young, healthy athletes exposed to Covid-19, the probability of receiving positive test results after day 10 of quarantine is low (less than 5%)
Time from Start of Quarantine to SARS-CoV-2 Positive Test Among Quarantined College and University Athletes — 17 States, June–October 2020 – CDC Morbidity and Mortality Weekly Report Commentary on Twitter A new @CDCMMWR looking at college athletes exposed to #COVID19 supports giving health departments options to potentially shorten quarantine periods to increase adherence. Learn […]
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CDC Study: Reducing quarantine to fewer than 14 days might be easier to comply with but carries some risk of spreading the virus
Implications of Shortened Quarantine Among Household Contacts of Index Patients with Confirmed SARS-CoV-2 Infection — Tennessee and Wisconsin, April–September 2020 – CDC Morbidity and Mortality Weekly Report Commentaries: Shorter Quarantines Can Eliminate Most Contagion. Is Most Enough? New Data – Brief19 AND Some Transmission of SARS-CoV-2 Occurs After Seven, 10 Days – Physician’s Wekly Related […]
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Randomized trial: Plasma therapy administered early is beneficial in high-risk elderly patients
Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults – New England Journal of Medicine Commentaries: Early convalescent plasma may lower risk of severe COVID in seniors – CIDRAP AND Covid-19: Early Plasma Treatment Improved Outcomes in Older Patients – Physician’s Weekly Commentaries on Twitter Just published @NEJM: A small, placebo-controlled randomized […]
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Blood plasma treatment has limited effect for sickest COVID-19 patients
Blood plasma treatment has limited effect for sickest COVID-19 patients – Imperial College London See also: Expert reaction to REMAP-CAP recruitment of severely ill COVID-19 patients into convalescent plasma trial being paused after initial analysis suggested it did not improve outcomes – Science Media Centre AND Trial of COVID-19 blood plasma finds no benefit in […]
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