M-A: Tocilizumab reduces the need for mechanical ventilation in COVID-19 patients, but the randomized trials included in the analysis showed it has no significant effect on the risk of mortality or adverse events
Efficacy and safety of tocilizumab in COVID-19 patients: A living systematic Review and meta-analysis: first update – Clinical Microbiology and Infection
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RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial – The Lancet Invited commentary: Tocilizumab in COVID-19: some clarity amid controversy – The Lancet
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Household COVID-19 risk and in-person schooling – “While in-person schooling is associated with household COVID-19 risk, this risk can likely be controlled with properly implemented school-based mitigation measures”
Household COVID-19 risk and in-person schooling – Science News Release: In-Person Schooling with Inadequate Mitigation Measures Raises Household Member’s COVID-19 Risk – Johns Hopkins Bloomberg School of Public Health Commentary on Twitter After analyzing responses from the #COVID19 Symptom Survey, @JustinLessler et al. find support for the idea that in-person schooling increases COVID-19 risk to […]
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Debate: Should masks be worn outdoors?
Should masks be worn outdoors? – The BMJ Commentaries: Experts debate on wearing masks outdoors – News Medical AND Do masks need to be worn outdoors? – Advanced Science News Commentary on Twitter (thread – click for more) Who do so many of us go off about outdoor masking? Because if governments can show […]
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Study with 6.9 million people in England shows severe Covid-19 in young people can mostly be explained by obesity – At a BMI of more than 23 kg/m2, there was a linear increase in risk of severe COVID-19
Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study – The Lancet Diabetes & Endocrinology Commentaries: Severe COVID in young people can mostly be explained by obesity – new study – The Conversation AND Obesity studies highlight severe COVID outcomes, even in young adults – CIDRAP AND […]
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AHA/ASA Guidance: Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – “No heparin products in any dose should be given.”
Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – Stroke News release: Guidance on treatment for rare blood clots and low platelets related to COVID-19 vaccine – American Heart Association Related: ISTH Interim Guidance for the Diagnosis and Treatment on Vaccine Induced Immune Thrombotic Thrombocytopenia
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FDA says it will ban all menthol cigarettes and flavored cigars
FDA says it will ban all menthol cigarettes and flavored cigars – STAT See also: FDA Moves To Ban Cigarettes And Flavored Cigars – NPR
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M-A: Delayed antibiotic prescribing for respiratory tract infections is a safe and effective strategy for most patients
Delayed antibiotic prescribing for respiratory tract infections: individual patient data meta-analysis – The BMJ Commentaries: Delayed Antibiotic Prescribing Safe for Respiratory Tract Infection – HealthDay
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ACP Guideline: Appropriate Use of High-Flow Nasal Oxygen in Hospitalized Patients – “use high-flow nasal oxygen rather than noninvasive ventilation in hospitalized adults for the management of acute hypoxemic respiratory failure”
Appropriate Use of High-Flow Nasal Oxygen in Hospitalized Patients for Initial or Postextubation Management of Acute Respiratory Failure: A Clinical Guideline From the American College of Physicians – Annals of Internal Medicine News release: ACP releases new recommendations for appropriate use of high-flow nasal oxygen in hospitalized patients with acute respiratory failure – American College […]
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Ethics Commission Position Statement: Admission criteria and management of critical care patients in a pandemic context – “Age cannot be used as the sole criterion for admission nor denial of access to ICU settings”
Admission criteria and management of critical care patients in a pandemic context: position of the Ethics Commission of the French Intensive Care Society, update of April 2021 – Annals of Intensive Care
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