Prior SARS-CoV-2 infection boosts response to variants after first vaccine dose
Prior SARS-CoV-2 infection boosts response to variants after first vaccine dose – Imperial College London Original study: Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose – Science Commentary on Twitter (thread – click for more) Just published @ScienceMagazine "After one dose, individuals with *prior infection* showed enhanced […]
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M-A: Prone positioning of nonintubated patients with Covid-19 improve oxygenation variables without any reported serious adverse events – randomized trials with patient-relevant outcomes such as the need for intubation or mortality rates are required
Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019—A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)
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[Preprint] Preventing disproportionate mortality in ICU overload situations: Empirical evidence from the first COVID-19 wave in Europe – “transferring patients proactively out of developing hotspots to less affected regions, well before high ICU workload
Preventing disproportionate mortality in ICU overload situations: Empirical evidence from the first COVID-19 wave in Europe – medRxiv
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Study: Patients with heart failure have a much higher incidence of pneumonia than matched individuals in the population. The development of pneumonia in these patients is associated with a 3- to 4-fold higher risk of cardiovascular and all-cause death.
Incidence and Outcomes of Pneumonia in Patients With Heart Failure – Journal of the American College of Cardiology Commentaries: Pneumonia in HF Patients Is Common, Lethal, and Preventable – TCTMD AND Outcomes of Pneumonia in Patients With Heart Failure – American College of Cardiology
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Shift work is associated with positive COVID-19 status in hospitalized patients
Shift work is associated with positive COVID-19 status in hospitalised patients – Thorax Commentary: Shift Work Linked to Increased Risk for COVID-19 Illness – HealthDay
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M-A: The viral shedding time (VST) determines disease transmission and the duration of infectiousness in SARS-CoV-2 infections – this study found that symptomatic infections, infected adults, persons with chronic diseases, and persons receiving corticoste
Characteristics of Viral Shedding Time in SARS-CoV-2 Infections: A Systematic Review and Meta-Analysis – Frontiers in Public Health
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Case series of 12 patients with cerebral venous sinus thrombosis with thrombocytopenia after Ad26.COV2.S vaccination – all women younger than 60 years, with symptoms from 6 to 15 days after vaccination
US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021 – JAMA Editorial: Assessing a Rare and Serious Adverse Event Following Administration of the Ad26.COV2.S Vaccine – JAMA See also: Safety Monitoring of the Janssen (Johnson & Johnson) COVID-19 Vaccine — United States, March–April 2021 – […]
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M-A: Tocilizumab reduces the need for mechanical ventilation in COVID-19 patients, but the randomized trials included in the analysis showed it has no significant effect on the risk of mortality or adverse events
Efficacy and safety of tocilizumab in COVID-19 patients: A living systematic Review and meta-analysis: first update – Clinical Microbiology and Infection
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RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial – The Lancet Invited commentary: Tocilizumab in COVID-19: some clarity amid controversy – The Lancet
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Household COVID-19 risk and in-person schooling – “While in-person schooling is associated with household COVID-19 risk, this risk can likely be controlled with properly implemented school-based mitigation measures”
Household COVID-19 risk and in-person schooling – Science News Release: In-Person Schooling with Inadequate Mitigation Measures Raises Household Member’s COVID-19 Risk – Johns Hopkins Bloomberg School of Public Health Commentary on Twitter After analyzing responses from the #COVID19 Symptom Survey, @JustinLessler et al. find support for the idea that in-person schooling increases COVID-19 risk to […]
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