RCT: Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels.
Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial – Nature Medicine Commentary on Twitter The SAVE-MORE phase 3 study demonstrates the efficacy of anakinra, an IL-1α/β inhibitor, in patients with COVID-19 and high serum levels of soluble plasminogen activator receptor, according […]
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More data showing increased risk of hospitalization with SARS-CoV-2 delta variant.
Hospitalisation associated with SARS-CoV-2 delta variant in Denmark – The Lancet Infectious Diseases Related study: Cohort study: Patients with Covid-19 infected with the Delta variant are twice as likely to need hospital admission or emergency care attendance.
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WHO says it is monitoring a new Covid variant called ‘mu’.
WHO says it is monitoring a new Covid variant called ‘mu’ – CNBC See also: What’s the Mu variant? And will we keep seeing more concerning variants? – The Conversation WHO monitoring new coronavirus variant named ‘Mu’ – France 24 New ‘mu’ coronavirus variant could escape vaccine-induced immunity, WHO says – LiveScience WHO monitoring new […]
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EU agency says to focus on vaccines first not booster shots.
EU agency says to focus on vaccines first not booster shots – Associated Press See also: European officials say COVID-19 booster isn’t urgent – CIDRAP
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Double vaccination halves risk of Long COVID.
News release: Double vaccination halves risk of Long COVID – King’s College London Original study: Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study – The Lancet Infectious Diseases Commentaries: Largest study of its kind finds face masks reduce COVID-19 […]
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[Preprint] Largest study of masks yet details their importance in fighting Covid-19.
Largest study of masks yet details their importance in fighting Covid-19 – NBC News Original study: The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh – Innovations for Poverty Action See also: A Study In Bangladesh Tripled The Rate Of Mask-Wearing. Can It Help In The U.S.? – NPR Commentaries on […]
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Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Waning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar – medRxiv Related: [Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease. Studies: COVID vaccine protection waning against infection but not hospitalization. Pfizer says it’s time for a Covid booster; FDA and […]
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Review | COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses.
COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses – The Lancet Rheumatology Commentary on Twitter NEW REVIEW—COVID-19 and immune-mediated inflammatory diseases Filippo Fagni and colleagues @UniFAU review the effect of disease and treatment on #COVID19 outcomes and #vaccine responseshttps://t.co/ue8XnDF1sM #LancetRheumatology @KorayTascilar pic.twitter.com/Yrk4SmeSbE — The Lancet Rheumatology […]
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RCT: Baricitinib reduced mortality in hospitalized adults with COVID-19.
Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial – The Lancet Respiratory Medicine Commentaries: Baricitinib: the first immunomodulatory treatment to reduce COVID-19 mortality in a placebo-controlled trial – The Lancet Respiratory Medicine Rheumatoid Arthritis Drug Combined with Standard of Care May […]
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RCT: In patients with acute hypoxemic respiratory failure, a strategy of lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal was not associated with improved outcomes.
Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial – JAMA (free for a limited period) Related: Randomized Trial: Low vs Intermediate Tidal Volume Strategy in ICU Patients Without ARDS Commentary on […]
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