RCT: Convalescent plasma does not improve outcomes and may be harmful to hospitalized patients with COVID-19.
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial – Nature Medicine News release: Major study finds convalescent plasma doesn’t help seriously ill COVID-19 patients – McMaster University Related: NIH study shows no significant benefit of convalescent plasma for COVID-19 outpatients with early symptoms. M-A: Convalescent plasma is safe but does not […]
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RCT: No benefit from Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis.
Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
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A large observational study suggests eating a plant-rich diet could reduce the risk of developing severe COVID-19.
Eating a plant rich diet reduces risk of developing COVID-19 – King’s College London Original study: Diet quality and risk and severity of COVID-19: a prospective cohort study – Gut
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Perspective | The plan to stop every respiratory virus at once – “The benefits of ventilation reach far beyond the coronavirus. What if we stop taking colds and flus for granted, too?”
The Plan to Stop Every Respiratory Virus at Once – The Atlantic Related: Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission. We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt. Report: Improved ventilation essential to safe use of buildings and public spaces, say leading engineers. WHO: Roadmap to […]
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[Preprint] RCT: Additional heterologous vs. homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination.
Additional heterologous versus homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination: a randomized controlled trial – medRxiv Commentary on Twitter (thread – click for more) Results of 60-person randomized trial of 3rd shot of mRNA or AZ vax in people on rituximab who didn't seroconvert after BNT-Pfizer (most) […]
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AstraZeneca bosses warn against rush for boosters – “giving the most vulnerable, who may not have built up a full immune response from the first two, a third, top-up dose is “sensible”. But any decision to give a third, booster jab “to large swathes of th
AstraZeneca bosses warn against rush for boosters – BBC Commentary on Twitter (thread – click for more) "Moving too quickly to boost across the entire adult population will deprive us of these insights, leaving this important decision to rest on limited data," Mr Soriot and Sir Mene write.https://t.co/xTAk7yyu5G — The Sharing Scientist (@ScienceShared) September […]
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[Preprint] Ineffective neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine sera.
Ineffective neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine sera – bioRxiv Related: United States boosts tracking of coronavirus strains as Mu variant draws scrutiny – Science Commentary on Twitter (thread – click for more) ?Bad news on #MuVariant—Japanese scientists: "Mu variant is highly resistant to sera from convalescent & [Pfizer]-vaccinated people. […]
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Spread of Delta SARS-CoV-2 variant driven by a combination of immune escape and increased infectivity.
News release: Spread of Delta SARS-CoV-2 variant driven by combination of immune escape and increased infectivity – University of Cambridge Original article: SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion – Nature
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Cochrane review: evidence is insufficient to draw meaningful conclusions if SARS‐CoV‐2-specific monoclonal antibodies are effective in the treatment of COVID-19.
Summary: Are laboratory-made, COVID-19-specific monoclonal antibodies an effective treatment for COVID-19? – Cochrane Library Original review: SARS‐CoV‐2‐neutralising monoclonal antibodies for treatment of COVID‐19 – Cochrane Library
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Isn’t it time to abandon ARDS? The COVID-19 lesson.
Isn’t it time to abandon ARDS? The COVID-19 lesson – Critical Care Commentary on Twitter #CritCare #OA #Gattinoni & #Marini: Keeping or abandoning #ARDS? ▶️ pros ▶️ conshttps://t.co/tIhusXT2S7#FOAMed #FOAMcc #BMC #COVID19 #Rx #RCT #PEEP #respiratory_failure #Personalized pic.twitter.com/M6aoiSAn3m — Critical Care (@Crit_Care) September 7, 2021
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