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[Preprint] M-A of 12.011.447 individuals finds individuals previously infected with SARS-CoV-2 had an 81% reduction in odds of a reinfection.

The prevalence of adaptive immunity to COVID-19 and reinfection after recovery, a comprehensive systematic review and meta-analysis of 12 011 447 individuals – medRxiv   Commentary on Twitter A new systematic review of over 12 million people from 54 studies at up to 8 months following Covid. >90% prevalence of IgG antibodies, reinfection 0.2% (an […]

The post [Preprint] M-A of 12.011.447 individuals finds individuals previously infected with SARS-CoV-2 had an 81% reduction in odds of a reinfection. appeared first on Links Medicus.

Opinion | Video: Immunity is the only way through a pandemic (w/Dr. Monica Gandhi).

Immunity Is The Only Way Through A Pandemic (w/Dr. Monica Gandhi) – ZDoggMD  

The post Opinion | Video: Immunity is the only way through a pandemic (w/Dr. Monica Gandhi). appeared first on Links Medicus.

Annual Update in Intensive Care and Emergency Medicine 2021 – Covid articles.

Secondary infections in critically ill patients with COVID-19 Tracheostomy for COVID-19: evolving best practice See also: Non-Covid articles  

The post Annual Update in Intensive Care and Emergency Medicine 2021 – Covid articles. appeared first on Links Medicus.

[Preprint] Large cohort study in Brazil showed AstraZeneca vaccine had high overall effectiveness against severe disease to individuals up to 89 years of age. In comparison, CoronaVac had high overall effectiveness against severe disease in individuals up

Extended intervals and extra doses of the AstraZeneca vaccine are associated with increased immunogenicity.

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002) – The Lancet Invited commentary: Longer intervals and extra doses of ChAdOx1 nCoV-19 vaccine   Commentaries on Twitter (thread – click for more) Substudy suggests extended interval […]

The post Extended intervals and extra doses of the AstraZeneca vaccine are associated with increased immunogenicity. appeared first on Links Medicus.

Interactive infographic showing the effects of Delta: How coronavirus spreads through a population and how we can beat it.

How coronavirus spreads through a population and how we can beat it – The Guardian  

The post Interactive infographic showing the effects of Delta: How coronavirus spreads through a population and how we can beat it. appeared first on Links Medicus.

Large surveillance study finds severe adverse events after COVID-19 mRNA vaccination are rare.

Surveillance for Adverse Events After COVID-19 mRNA Vaccination – JAMA Editorial: Safety Surveillance of COVID-19 mRNA Vaccines Through the Vaccine Safety Datalink – JAMA Commentaries: mRNA COVID vaccines not tied to serious side effects – CIDRAP Researchers find no serious health effects linked to mRNA COVID-19 vaccines – News Medical   Commentary on Twitter Concerned […]

The post Large surveillance study finds severe adverse events after COVID-19 mRNA vaccination are rare. appeared first on Links Medicus.

The resurgence of SARS-CoV-2 infection in a highly vaccinated health system workforce; vaccine effectiveness against infection was reduced from above 90% from March through June to 65% in July.

Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce – New England Journal of Medicine Related: Another study shows Pfizer mRNA vaccine immunity is reduced over time. Study shows AstraZeneca and Pfizer vaccines are effective against Delta variant, but both doses are needed.   Commentary on Twitter (thread – click for more) ? […]

The post The resurgence of SARS-CoV-2 infection in a highly vaccinated health system workforce; vaccine effectiveness against infection was reduced from above 90% from March through June to 65% in July. appeared first on Links Medicus.

RCT: Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels.

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial – Nature Medicine   Commentary on Twitter The SAVE-MORE phase 3 study demonstrates the efficacy of anakinra, an IL-1α/β inhibitor, in patients with COVID-19 and high serum levels of soluble plasminogen activator receptor, according […]

The post RCT: Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels. appeared first on Links Medicus.

More data showing increased risk of hospitalization with SARS-CoV-2 delta variant.

Hospitalisation associated with SARS-CoV-2 delta variant in Denmark – The Lancet Infectious Diseases Related study: Cohort study: Patients with Covid-19 infected with the Delta variant are twice as likely to need hospital admission or emergency care attendance.  

The post More data showing increased risk of hospitalization with SARS-CoV-2 delta variant. appeared first on Links Medicus.