Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review – JAMA Network Open Commentaries: Most COVID-19 survivors have symptoms 6 months on, review finds – CIDRAP Expert reaction to systematic review on rates of postacute sequelae of SARS-CoV-2 infection (PASC) – Science Media Centre How many people get ‘long COVID’? More […]
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Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico – medRxiv Commentary: Novel vaccine demonstrates high efficacy for prevention of COVID-19 – News Medical Related: RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths. Opinion | The mRNA vaccines are extraordinary, but Novavax […]
The post [Preprint] In RCT with 29,949 participants, the Novavax vaccine demonstrated high overall efficacy (>90%) for the prevention of Covid-19, and all moderate-to-severe cases occurred in placebo recipients. appeared first on Links Medicus.
Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-19 – PLOS Pathogens Commentary: Dose-dependent COVID-19 symptoms – Nature Reviews Microbiology Commentaries on Twitter When exposed to #SARSCoV2 why does one person have no illness, while another is soon in ICU?Dose.Controlled study in monkeys shows the dose of viruses inhaled is […]
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A primer on what we know about mixing and matching Covid vaccines – STAT Related: Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination. RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine. Another study shows increased immune response with […]
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WHO advisers recommend 3rd COVID vaccine dose for highest-risk groups – CIDRAP See also: WHO advises additional COVID shot for immunocompromised people – Reuters
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How antiviral pill molnupiravir shot ahead in the COVID drug hunt – Nature Related: What we know — and don’t know — about Merck’s new Covid-19 pill. [Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with […]
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Narrow-spectrum antibiotics for community-acquired pneumonia in Dutch adults (CAP-PACT): a cross-sectional, stepped-wedge, cluster-randomised, non-inferiority, antimicrobial stewardship intervention trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)
The post Cluster RCT: An antimicrobial stewardship intervention safely reduced the use of broad-spectrum antibiotics among patients hospitalized with moderately severe community-acquired pneumonia. appeared first on Links Medicus.
D-Dimer Testing for the Exclusion of Pulmonary Embolism Among Hospitalized Patients With COVID-19 – JAMA Network Open Commentary: D-Dimer Level Not Useful for Ruling Out PE in COVID-19 Patients – HealthDay
The post D-Dimer testing for the exclusion of pulmonary embolism has limited clinical utility among hospitalized patients with COVID-19 – most patients with or without pulmonary embolism have increased levels. appeared first on Links Medicus.
Why easing COVID restrictions could prompt a fierce flu rebound – Nature
The post Why easing COVID restrictions could prompt a fierce flu rebound – “As pandemic restrictions ease, other respiratory viruses are returning in unexpected ways”. appeared first on Links Medicus.
Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial – JAMA Editorial: Antithrombotic Therapy for Outpatients With COVID-19: Implications for Clinical Practice and Future Research – JAMA Commentary on Twitter Data do not support the use of aspirin or apixaban in the outpatient setting […]
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