Bibliographie (2530)
Review: Lung Transplantation
samedi, 16 novembre 2024 14:35 Écrit par Zouhair SouissiIntroduction: Lung transplantation has progressed from experimental to standard therapy for life-threatening lung diseases, offering improved survival and quality of life. Challenges include primary graft dysfunction, chronic lung allograft dysfunction (CLAD), infections, and long-term immunosuppression effects. This review highlights current practices, developments, and opportunities to enhance this transformative therapy. Key Recommendations Candidate Selection: Selection criteria […]
The post Review: Lung Transplantation appeared first on Links Medicus.
RCT: ICS-Formoterol and ICS-SABA Reduce Severe Asthma Exacerbations Compared With SABA Alone
lundi, 28 octobre 2024 19:18 Écrit par Zouhair SouissiBackground: Asthma affects millions worldwide and is managed using inhaled relievers to alleviate acute symptoms. While short-acting β agonists (SABA) are commonly used, combining inhaled corticosteroids (ICS) with SABA or formoterol may enhance outcomes. Recent guidelines recommend ICS-formoterol as the preferred reliever, but the optimal choice remains uncertain, especially following the recent FDA approval of […]
The post RCT: ICS-Formoterol and ICS-SABA Reduce Severe Asthma Exacerbations Compared With SABA Alone appeared first on Links Medicus.
ATS Guideline: Evaluation and Management of Obesity Hypoventilation Syndrome
dimanche, 13 octobre 2024 02:31 Écrit par Zouhair SouissiIntroduction: Obesity Hypoventilation Syndrome (OHS) is a serious condition characterized by obesity (BMI ≥30 kg/m²), sleep-disordered breathing, and daytime hypercapnia (PaCO₂ ≥45 mm Hg), after excluding other causes of hypoventilation. Recognizing the need for standardized evaluation and management, the American Thoracic Society (ATS) has developed comprehensive guidelines. These aim to improve early recognition, optimize treatment […]
The post ATS Guideline: Evaluation and Management of Obesity Hypoventilation Syndrome appeared first on Links Medicus.
RCT: Telehealth-Delivered Early Palliative Care Equivalent to In-Person Care in Advanced Lung Cancer
jeudi, 26 septembre 2024 18:09 Écrit par Zouhair SouissiBackground: Patients with advanced lung cancer often face a high symptom burden and decreased quality of life (QOL), but access to early palliative care, which can improve these outcomes, remains limited. While telehealth has become increasingly utilized due to the COVID-19 pandemic, it is unclear whether virtual palliative care is as effective as in-person care. […]
The post RCT: Telehealth-Delivered Early Palliative Care Equivalent to In-Person Care in Advanced Lung Cancer appeared first on Links Medicus.
Summary: Perioperative Management of Patients Taking Direct Oral Anticoagulants
jeudi, 19 septembre 2024 23:39 Écrit par Zouhair SouissiDirect oral anticoagulants (DOACs)—including apixaban, rivaroxaban, edoxaban, and dabigatran—are increasingly used for stroke prevention in atrial fibrillation and for treating venous thromboembolism. Effective perioperative management of DOACs is essential to minimize bleeding and thromboembolic risks during surgical and nonsurgical procedures. Below are practical recommendations focused on the perioperative management of patients taking DOACs, based on […]
The post Summary: Perioperative Management of Patients Taking Direct Oral Anticoagulants appeared first on Links Medicus.
Summary: Community-Acquired Pneumonia
jeudi, 19 septembre 2024 19:45 Écrit par Zouhair SouissiIntroduction Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality, accounting for approximately 1.4 million emergency department visits, 740,000 hospitalizations, and 41,000 deaths annually in the United States. Effective management of CAP requires prompt and accurate diagnosis, appropriate antimicrobial therapy, and consideration of adjunctive treatments. This summary highlights key practice points from a […]
The post Summary: Community-Acquired Pneumonia appeared first on Links Medicus.
RCT: Twice-Yearly Depemokimab Reduced Exacerbations in Severe Eosinophilic Asthma
mercredi, 18 septembre 2024 01:03 Écrit par Zouhair SouissiBackground: Severe asthma with an eosinophilic phenotype often leads to frequent exacerbations despite treatment with medium- or high-dose inhaled glucocorticoids and additional controllers. Interleukin-5 is pivotal in eosinophil growth and survival, contributing to airway inflammation. Existing biologic therapies targeting interleukin-5 require frequent dosing intervals. Depemokimab is an ultra-long-acting anti–interleukin-5 biologic with enhanced binding affinity, potentially […]
The post RCT: Twice-Yearly Depemokimab Reduced Exacerbations in Severe Eosinophilic Asthma appeared first on Links Medicus.
RCT: High-Intensity NPPV Reduced Criteria for Intubation in Acute COPD Exacerbations
lundi, 16 septembre 2024 19:43 Écrit par Zouhair SouissiBackground: Acute exacerbations of chronic obstructive pulmonary disease (COPD) often lead to hypercapnic respiratory failure requiring ventilatory support. Noninvasive positive pressure ventilation (NPPV) is standard care, commonly delivered at low intensity with lower inspiratory pressures. However, approximately 15% of patients still require endotracheal intubation despite low-intensity NPPV. High-intensity NPPV, using higher inspiratory pressures to achieve […]
The post RCT: High-Intensity NPPV Reduced Criteria for Intubation in Acute COPD Exacerbations appeared first on Links Medicus.
Review | Reducing errors resulting from commonly missed chest radiography findings
samedi, 14 septembre 2024 15:13 Écrit par Zouhair SouissiReducing Errors Resulting From Commonly Missed Chest Radiography Findings – CHEST (free for a limited period) See also: Commonly Missed Findings on Chest Radiographs: Causes and Consequences – CHEST (free for a limited period)
The post Review | Reducing errors resulting from commonly missed chest radiography findings appeared first on Links Medicus.
M-A | Routine anaerobic coverage for aspiration pneumonia: limited evidence of benefit
samedi, 14 septembre 2024 15:13 Écrit par Zouhair SouissiSummary: Treating aspiration pneumonia with antibiotics that cover anaerobic bacteria has become common practice in many services, but recent studies suggest that this may not necessarily improve prognosis. Out of 2523 publications, this systematic review and meta-analysis only included one randomized control trial and two observational studies. The study found no clear benefit of anaerobic […]
The post M-A | Routine anaerobic coverage for aspiration pneumonia: limited evidence of benefit appeared first on Links Medicus.
