Bibliographie (2544)
Network Meta-analysis: Oseltamivir Fails to Improve Key Outcomes in Nonsevere Influenza
jeudi, 30 janvier 2025 02:24 Écrit par Zouhair SouissiBackground: Influenza causes significant respiratory morbidity and can lead to severe complications, especially in high-risk individuals. Current guidelines endorse antiviral therapy, yet the evidence for reducing mortality, hospital admission, and symptom duration in nonsevere cases remains controversial. Recent recommendations have often focused on neuraminidase inhibitors (e.g., oseltamivir), despite uncertainties regarding clinical impact and adverse effects. […]
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Introducing Our Free WhatsApp Channels for Daily Internal Medicine Articles!
jeudi, 30 janvier 2025 02:24 Écrit par Zouhair SouissiWe’re pleased to share our new WhatsApp channels, designed to provide daily articles in Internal Medicine. Whether you’re a busy healthcare professional or an enthusiast keen to stay updated on the latest research, these channels might be just what you need. Why Join Our WhatsApp Channels? Concise Summaries, Straight to Your Phone: Each morning, you’ll […]
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Multidrug-resistant Gram-negative bacterial infections: Key Updates and Practical Strategies
jeudi, 30 janvier 2025 02:24 Écrit par Zouhair SouissiIntroduction: This summary highlights essential points from a recent review in The Lancet addressing multidrug-resistant Gram-negative bacterial (MDR-GNB) infections. It discusses the global epidemiology, diagnostic advances, and therapeutic approaches, aiming to guide clinicians in managing these difficult-to-treat pathogens, which include resistant Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii. Key Recommendations: Use Rapid Diagnostics to Guide Therapy […]
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RCT: High-Flow Nasal Oxygen Noninferior to Noninvasive Ventilation for Most Acute Respiratory Failure Causes
lundi, 13 janvier 2025 15:35 Écrit par Zouhair SouissiBackground: Acute respiratory failure (ARF) arises from diverse etiologies and can manifest as hypoxemic or hypercapnic events. High-flow nasal oxygen (HFNO) and noninvasive ventilation (NIV) are common noninvasive respiratory support modalities, but robust comparative data in various ARF subgroups have been limited. Prior research suggests NIV may benefit chronic obstructive pulmonary disease (COPD) exacerbations and […]
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2024 Focused Guideline Update on Corticosteroid Use in Sepsis, ARDS, and Community-Acquired Pneumonia
lundi, 13 janvier 2025 12:55 Écrit par Zouhair SouissiIntroduction: This summary presents the key points from a 2024 focused update of the guidelines on corticosteroid use for hospitalized adult patients with sepsis, acute respiratory distress syndrome (ARDS), and community-acquired pneumonia (CAP). Developed by a panel of international experts in critical care, endocrinology, and methodology, the update aims to incorporate new evidence into recommendations […]
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Network Meta-Analysis: TMP-SMX May Need Reassessment as First-Line Therapy for PCP in People With HIV
lundi, 13 janvier 2025 12:55 Écrit par Zouhair SouissiBackground: Pneumocystis jirovecii pneumonia (PCP) remains a severe opportunistic infection in people living with HIV (PWH), especially those with low CD4 counts. Trimethoprim–sulfamethoxazole (TMP-SMX) is widely recommended as first-line therapy; however, its toxicity profile can limit use. Alternative regimens such as dapsone–trimethoprim, clindamycin–primaquine, atovaquone, and pentamidine have been explored, but comprehensive comparative data are scarce. […]
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RCT: Assessing Procalcitonin-Based Antibiotic Management in Critically Ill Patients With Sepsis
mardi, 07 janvier 2025 15:11 Écrit par Zouhair SouissiBackground: Optimal antibiotic duration for sepsis remains uncertain. Procalcitonin (PCT) and C-reactive protein (CRP) are thought to support shorter courses, but prior research was small-scale or at risk of bias. This multicenter, randomized trial (ADAPT-Sepsis) evaluated whether daily PCT- or CRP-guided protocols could reduce antibiotic use without increasing 28-day all-cause mortality in critically ill adults with […]
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ATS Guidelines on Invasive Pulmonary Aspergillosis and Antifungal Strategies in Critically Ill Adults
mardi, 07 janvier 2025 14:08 Écrit par Zouhair SouissiIntroduction: This summary provides an overview of a recent American Thoracic Society clinical practice guideline addressing two core questions in adult pulmonary and critical care practice. First, it examines whether combination therapy with a mold-active triazole (most data concern voriconazole, though newer agents such as isavuconazole or posaconazole may also be considered) plus an echinocandin […]
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Meta-analysis: Therapeutic-Dose Heparin Improves 28-Day Mortality in COVID-19 Hospitalized Patients
lundi, 06 janvier 2025 13:31 Écrit par Zouhair SouissiBackground: High rates of thrombotic events and systemic inflammation among COVID-19 hospitalized patients led researchers to test whether intensified anticoagulation strategies could reduce morbidity and mortality. Previous trials yielded conflicting results, partly due to varying doses of anticoagulants—prophylactic, intermediate, or therapeutic—and heterogeneous patient severity. This comprehensive investigation, conducted by the WHO Rapid Evidence Appraisal for COVID-19 […]
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Joint ATS/CDC/ERS/IDSA Guideline Recommends Shorter, All-Oral Regimens for Drug-Susceptible and Drug-Resistant TB
dimanche, 05 janvier 2025 13:08 Écrit par Zouhair SouissiIntroduction: This summary outlines new clinical practice guidelines from the American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America on updated treatment regimens for tuberculosis (TB) in low-incidence settings. These recommendations build on recent clinical trials, World Health Organization (WHO) guidance, and were developed using […]
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