Bibliographie (2528)
ATS Guideline: Evaluation and Management of Obesity Hypoventilation Syndrome
dimanche, 13 octobre 2024 02:31 Écrit par Zouhair SouissiIntroduction: Obesity Hypoventilation Syndrome (OHS) is a serious condition characterized by obesity (BMI ≥30 kg/m²), sleep-disordered breathing, and daytime hypercapnia (PaCO₂ ≥45 mm Hg), after excluding other causes of hypoventilation. Recognizing the need for standardized evaluation and management, the American Thoracic Society (ATS) has developed comprehensive guidelines. These aim to improve early recognition, optimize treatment […]
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RCT: Telehealth-Delivered Early Palliative Care Equivalent to In-Person Care in Advanced Lung Cancer
jeudi, 26 septembre 2024 18:09 Écrit par Zouhair SouissiBackground: Patients with advanced lung cancer often face a high symptom burden and decreased quality of life (QOL), but access to early palliative care, which can improve these outcomes, remains limited. While telehealth has become increasingly utilized due to the COVID-19 pandemic, it is unclear whether virtual palliative care is as effective as in-person care. […]
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Summary: Perioperative Management of Patients Taking Direct Oral Anticoagulants
jeudi, 19 septembre 2024 23:39 Écrit par Zouhair SouissiDirect oral anticoagulants (DOACs)—including apixaban, rivaroxaban, edoxaban, and dabigatran—are increasingly used for stroke prevention in atrial fibrillation and for treating venous thromboembolism. Effective perioperative management of DOACs is essential to minimize bleeding and thromboembolic risks during surgical and nonsurgical procedures. Below are practical recommendations focused on the perioperative management of patients taking DOACs, based on […]
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Summary: Community-Acquired Pneumonia
jeudi, 19 septembre 2024 19:45 Écrit par Zouhair SouissiIntroduction Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality, accounting for approximately 1.4 million emergency department visits, 740,000 hospitalizations, and 41,000 deaths annually in the United States. Effective management of CAP requires prompt and accurate diagnosis, appropriate antimicrobial therapy, and consideration of adjunctive treatments. This summary highlights key practice points from a […]
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RCT: Twice-Yearly Depemokimab Reduced Exacerbations in Severe Eosinophilic Asthma
mercredi, 18 septembre 2024 01:03 Écrit par Zouhair SouissiBackground: Severe asthma with an eosinophilic phenotype often leads to frequent exacerbations despite treatment with medium- or high-dose inhaled glucocorticoids and additional controllers. Interleukin-5 is pivotal in eosinophil growth and survival, contributing to airway inflammation. Existing biologic therapies targeting interleukin-5 require frequent dosing intervals. Depemokimab is an ultra-long-acting anti–interleukin-5 biologic with enhanced binding affinity, potentially […]
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RCT: High-Intensity NPPV Reduced Criteria for Intubation in Acute COPD Exacerbations
lundi, 16 septembre 2024 19:43 Écrit par Zouhair SouissiBackground: Acute exacerbations of chronic obstructive pulmonary disease (COPD) often lead to hypercapnic respiratory failure requiring ventilatory support. Noninvasive positive pressure ventilation (NPPV) is standard care, commonly delivered at low intensity with lower inspiratory pressures. However, approximately 15% of patients still require endotracheal intubation despite low-intensity NPPV. High-intensity NPPV, using higher inspiratory pressures to achieve […]
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Review | Reducing errors resulting from commonly missed chest radiography findings
samedi, 14 septembre 2024 15:13 Écrit par Zouhair SouissiReducing Errors Resulting From Commonly Missed Chest Radiography Findings – CHEST (free for a limited period) See also: Commonly Missed Findings on Chest Radiographs: Causes and Consequences – CHEST (free for a limited period)
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M-A | Routine anaerobic coverage for aspiration pneumonia: limited evidence of benefit
samedi, 14 septembre 2024 15:13 Écrit par Zouhair SouissiSummary: Treating aspiration pneumonia with antibiotics that cover anaerobic bacteria has become common practice in many services, but recent studies suggest that this may not necessarily improve prognosis. Out of 2523 publications, this systematic review and meta-analysis only included one randomized control trial and two observational studies. The study found no clear benefit of anaerobic […]
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M-A | Pretest probability assessment and D-Dimer are preferred for the initial evaluation of suspected PE in pregnant women
samedi, 14 septembre 2024 15:13 Écrit par Zouhair SouissiNoninvasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data – Journal of Thrombosis and Haemostasis
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RCT | Sotatercept improves exercise capacity in patients with pulmonary arterial hypertension
samedi, 14 septembre 2024 15:13 Écrit par Zouhair SouissiSummary: This multicenter, double-blind randomized trial involved 323 adults with Pulmonary Arterial Hypertension (PAH) who were randomized to receive either subcutaneous sotatercept or placebo every three weeks for 24 weeks. The primary endpoint was the change from baseline in the 6-minute walk distance. Sotatercept demonstrated a greater improvement in exercise capacity compared to placebo and […]
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