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Predictive equations for CPAP titration in OSAS patients

Conclusions  Manual or auto CPAP titration remains the best way to define the appropriate CPAP. However, predictive formulas can be useful if used with caution and always after verifying the real efficacy, particularly for patients needing higher pressure.

A Specific Enzyme Inhibitor May Help Control Lung Inflammation

All of us may be able to breathe a little easier now that scientists from Pennsylvania have found a new therapeutic target for controlling dangerous inflammation in the lungs.
A new research report in the January 2011 issue of the Journal of Leukocyte Biology suggests that blocking the activation of an enzyme called delta-protein kinase C (delta-PKC) could protect the lungs from neutrophil-mediated damage, which can result in out of control inflammation...

 

Design of the exhale airway Stents for emphysema (EASE) trial: an endoscopic procedure for reducing hyperinflation

Airway Bypass is a catheter-based, bronchoscopic procedure in which new passageways are created that bypass the collapsed airways, enabling trapped air to exit the lungs. The Exhale Airway Stents for Emphysema (EASE) Trial was designed to investigate whether Exhale Drug-Eluting stents, placed in new passageways in the lungs, can improve pulmonary function and reduce breathlessness in severely hyperinflated, homogeneous emphysema patients (NCT00391612).

Methods: The multi-center, randomized, double-blind, sham-controlled trial design was posted on www.clinicaltrials.gov in October 2006. Because Bayesian statistics are used for the analysis, the proposed enrollment ranged from 225 up to 450 subjects at up to 45 institutions. Inclusion criteria are: high resolution CT scan with ev...

Poorly Treated or Unrecognized GERD Reduces Quality of Life in Patients with COPD

Conclusion  Patients with COPD and continuing GERD symptoms have reduced HRQL in comparison with those with COPD alone.

 

Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis

Conclusions: Passive smoking in the family home is a major influence on the risk of LRI in infants, and especially on bronchiolitis. Risk is particularly strong in relation to post-natal maternal smoking. Strategies to prevent passive smoke exposure in young children are an urgent public and child health priority.

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