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A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screening

Conclusions: This staged biophysical screening paradigm provides proof-of-principle for high-throughput and cost-effective discovery of new small molecule therapeutic agents for obstructive lung diseases.

Sleep Disorders - Breathing

In one of the largest studies of its kind Danish sleep researchers from the University of Copenhagen and the Danish Institute for Health Services Research have examined the socio-economic consequences of the sleep disorders snoring, sleep apnoea, and obesity-related respiratory difficulties (obesity hypoventilation syndrome (OHS)).

These disorders are a serious health and social-economic burden on the individual and on society as a whole.

Adherence to action plan reduces COPD exacerbation recovery time

Patients with chronic obstructive pulmonary disease can minimize their recovery time after an exacerbation by sticking to a written action plan, research shows.

Prognostic value of N-terminal pro-brain natriuretic peptide in hospitalised patients with community-acquired pneumonia

Conclusions NT-proBNP level is an independent predictor of mortality in hospitalised CAP patients. The performance of NT-proBNP level is comparable to those of PSI and CURB65 in predicting mortality.

Critical care in the emergency department: acute respiratory failure

Acute respiratory failure (ARF) is a frequent emergency department (ED) presentation. The definition and common causes of ARF are discussed in this article and ED management of the condition is discussed, using an illustrative case report.

The paper considers the role of B-type natriuretic peptide in diagnosis and non-invasive ventilation (NIV) in treatment. Intensive care unit admission denial is common in ARF, although the evidence base is lacking. Finally, the decision-making process is described when a patient with ARF fails to improve with NIV.

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