A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screening
In one of the largest studies of its kind Danish sleep researchers from the University of Copenhagen and the Danish Institute for Health Services Research have examined the socio-economic consequences of the sleep disorders snoring, sleep apnoea, and obesity-related respiratory difficulties (obesity hypoventilation syndrome (OHS)).
These disorders are a serious health and social-economic burden on the individual and on society as a whole.
Acute respiratory failure (ARF) is a frequent emergency department (ED) presentation. The definition and common causes of ARF are discussed in this article and ED management of the condition is discussed, using an illustrative case report.
The paper considers the role of B-type natriuretic peptide in diagnosis and non-invasive ventilation (NIV) in treatment. Intensive care unit admission denial is common in ARF, although the evidence base is lacking. Finally, the decision-making process is described when a patient with ARF fails to improve with NIV.