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Termination of Respiratory Events with and without Cortical Arousal in Obstructive Sleep Apnea.

CONCLUSIONS: Respiratory events that were terminated with ASDA-Arousal were more severely flow-limited, had enhanced hyperventilation after event termination and were more often followed by secondary events than No-Arousal. However, secondary events were not associated with low dilator muscle activity and airflow was improved following both No-Arousal and ASDA-Arousal. PMID: 21836132 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

The effects of CPAP therapy withdrawal in patients with obstructive sleep apnea: a randomised controlled trial.

CONCLUSIONS: CPAP withdrawal usually leads to a rapid recurrence of OSA, a return of subjective sleepiness and is associated with impaired endothelial function, increased urinary catecholamines, blood pressure and heart rate. Thus the proposed study model appears to be suitable to evaluate physiological and therapeutic effects in OSA. www.controlled-trials.com (ISRCTN 93153804). PMID: 21836134 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

The Response of Children with Asthma to Ambient Particulate is Modified by Tobacco Smoke Exposure.

CONCLUSIONS: This study suggests that ETS modifies the acute effects of low-level ambient PM2.5 exposure on childhood asthma. This negative interaction, the smaller effect of particulate matter exposure in children exposed to higher ETS, may be related to a nonlinear dose-response relationship between asthma mediators and particulate exposures. PMID: 21868505 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

Screening and Prevention of Venous Thromboembolism in Critically Ill Patients: A Decision Analysis and Economic Evaluation.

CONCLUSION: Appropriate prophylaxis provides better value in terms of costs and health gains than routine screening for DVT. Resources should be targeted at optimizing thromboprophylaxis. PMID: 21868500 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

The Societal Impact of Single Versus Bilateral Lung Transplantation for Chronic Obstructive Pulmonary Disease.

CONCLUSIONS: In most circumstances, a policy of single lung transplantation for COPD will improve access to organs for other potential recipients without significant reductions in total post-transplant survival. However, there may be substantial geographic variations in the effect of such a policy on the balance between these outcomes. PMID: 21868502 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

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