Author contributions: R.M. Andrianasolo, S. Hercberg, P. Galan, E. Kesse-Guyot and R. Varraso designed and conducted the research; E. Kesse-Guyot, M. Adjibade, S. Hercberg, P. Galan and R. Varraso provided essential reagents or provided essential materials; R.M. Andrianasolo and R.
Despite the gain in terms of hospital survival achieved in the last decades though the application of Surviving Sepsis Campaign (SSC) guidelines, the treatment of sepsis remains challenging for clinicians as
While targeted nonsmall cell lung cancer (NSCLC) therapies have improved the outcome of defined disease subtypes, prognosis for most patients remains poor. We found the AAA+ ATPase Reptin to be
Chronic obstructive pulmonary disease (COPD) is a major economic and social concern worldwide because of its impact on mortality and morbidity [1]. COPD is characterised by airway epithelium remodelling, a hallmark of dysregulated airway epithelium plasticity [2]. There are currently no available therapeutics to restore the integrity and functionality of the epithelium. Therefore, novel sources of investigation are becoming crucial to understand the alterations at the root of COPD initiation.
Antibiotic use during infancy alters gut microbiota and immune development and is associated with an increased risk of childhood asthma. The impact of prenatal antibiotic exposure is unclear. We sought to characterise the association between prenatal antibiotic exposure and childhood asthma.
We performed a population-based cohort study using prescription records, hospitalisation records and physician billing claims from 213 661 mother–child dyads born in Manitoba, Canada between 1996 and 2012. Associations were determined using Cox regression, adjusting for maternal asthma, postnatal antibiotics and other potential confounders. Sensitivity analyses evaluated maternal antibiotic use before and after pregnancy.