Multi-omic molecular profiling of lung cancer in COPD
Chronic obstructive pulmonary disease (COPD) is a known risk factor for developing lung cancer but the underlying mechanisms remain unknown. We hypothesise that the COPD stroma contains molecular mechanisms supporting tumourigenesis.
We conducted an unbiased multi-omic analysis to identify gene expression patterns that distinguish COPD stroma in patients with or without lung cancer. We obtained lung tissue from patients with COPD and lung cancer (tumour and adjacent non-malignant tissue) and those with COPD without lung cancer for profiling of proteomic and mRNA (both cytoplasmic and polyribosomal). We used the Joint and Individual Variation Explained (JIVE) method to integrate and analyse across the three datasets.
Prenatal antibiotic exposure and childhood asthma: a population-based study
Antibiotic use during infancy alters gut microbiota and immune development and is associated with an increased risk of childhood asthma. The impact of prenatal antibiotic exposure is unclear. We sought to characterise the association between prenatal antibiotic exposure and childhood asthma.
We performed a population-based cohort study using prescription records, hospitalisation records and physician billing claims from 213 661 mother–child dyads born in Manitoba, Canada between 1996 and 2012. Associations were determined using Cox regression, adjusting for maternal asthma, postnatal antibiotics and other potential confounders. Sensitivity analyses evaluated maternal antibiotic use before and after pregnancy.
Understanding patients' perceptions of asthma control: a qualitative study
Conflict of interest: N. Barnes is employed by and holds shares in GSK. R. Horne reports personal fees for speaker engagements from AbbVie, Amgen, Biogen, Idec, Gilead Sciences, GSK, Janssen, Pfizer, Roche, Shire Pharmaceuticals,
"Number needed to treat: enigmatic results for exacerbations in COPD." Samy Suissa. Eur Respir J 2015; 45: 875-878.
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Nasopharyngeal aspirate value in paediatric chronic lower respiratory tract illness
Extract
Respiratory viruses are a common cause of illness in children and are responsible for high morbidity and hospitalisation [1]. The role of infectious agents in chronic/recurrent lower respiratory tract illness