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Autoimmune pulmonary alveolar proteinosis: Treatment options in year 2013

ABSTRACT Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of a periodic acid Schiff (PAS)‐positive eosinophilic material in the distal airways. For decades, the standard treatment of PAP has been whole lung lavage (WLL), where large quantities of saline are instilled into the lungs to remove the proteinaceous material. However, not all patients respond to this treatment. Thus, new treatment modalities, such as subcutaneous or inhaled granulocyte macrophage colony‐stimulating factor (GM‐CSF), and the CD20 antibody rituximab and plasmapheresis, have been investigated. Based on the current literature, a stepwise treatment plan is suggested starting with WLL, continuing to inhaled GM‐CSF, and then to rituximab if the former treatment regimes are...

Obesity and respiratory disease—weighing in on the issue: An epilogue

(Source: Respirology)

Neurocognitive function in obstructive sleep apnoea: A meta‐review

ABSTRACT Adult obstructive sleep apnoea (OSA) is associated with cognitive dysfunction. While many review articles have attempted to summarize the evidence for this association, it remains difficult to determine which domains of cognition are affected by OSA. This is because of marked differences in the nature of these reviews (e.g. many are unsystematic) and the many different tasks and domains assessed. This paper addresses this issue by comparing the results of only systematic reviews or meta‐analyses assessing the effects of OSA on cognition, the relationship between OSA severity and cognition, and/or the effects of treatment on cognition in OSA. Electronic databases and hand‐searching were undertaken to select reviews that reported on these areas. We found 33 reviews; five reviews...

The consortium for the standardization of influenza seroepidemiology (CONSISE): a global partnership to standardize influenza seroepidemiology and develop influenza investigation protocols to inform public health policy

CONSISE – The consortium for the Standardization of Influenza Seroepidemiology – is a global partnership to develop influenza investigation protocols and standardize seroepidemiology to inform health policy. This international partnership was formed in 2011 and was created out of a need, identified during the 2009 H1N1 pandemic, for timely seroepidemiological data to better estimate pandemic virus infection severity and attack rates to inform policy decisions. CONSISE has developed into a consortium of two interactive working groups: epidemiology and laboratory, with a steering committee composed of individuals from several organizations. CONSISE has had two international meetings with more planned for 2013. We seek additional members from public health agencies, academic institutions ...

Asthmatics At Increased Risk Of Pulmonary Embolism

People with asthma have an increased risk of pulmonary embolism, according to new research. A new study, published online ahead of print today (20 December 2012) in the European Respiratory Journal, looked at whether people with moderate or severe asthma had an increased risk of developing deep vein thrombosis, or pulmonary embolism. Pulmonary embolism is when the main artery of the lung or the bronchi becomes blocked. It usually results from deep vein thrombosis; a blood clot in the veins, which can break off and move around the body to the lung... (Source: Health News from Medical News Today)

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