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Middle East respiratory syndrome coronavirus (MERS-CoV) – update (United Arab Emirates)

On 10 July 2014, the National IHR Focal Point for the United Arab Emirates (UAE) reported 2 additional laboratory-confirmed cases of infection with Middle East respiratory syndrome coronavirus (MERS-CoV).

A 67-year-old man from Abu Dhabi, UAE who became ill on 17 June and was admitted to a hospital on the same day. On 2 July 2014, the patient was critically ill and was admitted to the intensive care unit in a hospital in Abu Dhabi. He was laboratory-confirmed with MERS-CoV infection on 6 July. The patient is reported to have underlying medical conditions.

The patient owns a camel farm in the Eastern Region of Saudi Arabia. He visited his farm 3 months prior to becoming ill and had direct contact with camels. Two weeks prior to becoming ill, he visited a camel farm in Abu Dhabi, where he d...

Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most commonly involved in hypersensitivity drug reactions. Such reactions can be due to the release of inflammatory mediators in the absence of specific immunologic recognition, or immunoglobulin E (IgE)- or T-cell–selective responses.

The former include upper and lower airway symptoms in patients with chronic underlying respiratory disease, the exacerbation of chronic spontaneous urticaria, and the induction of cutaneous symptoms.

The latter include selective responses to a single NSAID with good tolerance to strong cyclooxygenase-1 inhibitors, with a putative IgE or T-cell mechanism proposed. These reactions can be acute or delayed.

Development of antibiotic treatment algorithms based on local ecology and respiratory surveillance cultures to restrict the use of broad-spectrum antimicrobial drugs in the treatment of hospital-acquired pneumonia in the intensive care unit: a retrospecti

Using a surveillance culture-based algorithm could reduce the use of broad-spectrum antibiotics and may be preferable when implementing new stewardship programs.

Combined pulmonary fibrosis and emphysema: an increasingly recognized condition

Combined pulmonary fibrosis and emphysema (CPFE) has been increasingly recognized in the literature. Patients with CPFE are usually heavy smokers or former smokers with concomitant lower lobe fibrosis and upper lobe emphysema on chest HRCT scans. They commonly present with severe breathlessness and low DLCO, despite spirometry showing relatively preserved lung volumes. Moderate to severe pulmonary arterial hypertension is common in such patients, who are also at an increased risk of developing lung cancer. Unfortunately, there is currently no effective treatment for CPFE.

In this review, we discuss the current knowledge of the pathogenesis, clinical characteristics, and prognostic factors of CPFE. Given that most of the published data on CPFE are based on retrospective analysis, more studi...

Oxygen desaturation during the six-minute walk test in COPD patients

Conclusions: In the sevCOPD group, in comparison with the modCOPD group, SpO2 was lower and the Tmin was greater, suggesting a worse prognosis in the former.

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