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Role of Omalizumab in Children With Difficult to Control Asthma

Omalizumab is a humanized monoclonal antibody used in the treatment of moderate to severe allergic asthma in children over 12 years and adults. There are many adult studies that have shown it to be a safe drug. The adult clinical trials show improvement in clinical outcomes for patients on omalizumab but reports on its real-life use in children are few. Additional studies for the use of omalizumab in pediatric population are needed. The aim of this paper is to review the limited pediatric literature and compare with a retrospective chart review done for pediatric patients taking omalizumab at a tertiary pulmonary clinic with moderate to severe allergic asthma. A review of the recent pediatric studies was compared with a retrospective chart review on all patients prescribed Xolair (omalizum...

Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disorder and ultimately fatal disease. Acute exacerbation of IPF (AE-IPF) is defined as a rapid deterioration with new radiographic opacities in patients with IPF with no identifiable cause such as infection, pulmonary embolism, or heart failure. Reported incidence of this disease entity is highly variable and the etiology is unknown. Research into the pathobiology of this process has implicated possible causes including microaspirations and occult viral infection. AE-IPF manifests histopathologically as diffuse alveolar damage and can have features of organizing pneumonia in the later phase. High-resolution computed tomography of the chest demonstrates new ground-glass opacities and can have prognostic value based on the patter...

Dual Therapy for Smoking Cessation

Synopsis: Dual nicotine receptor stimulation with varenicline and nicotine replacement therapy (NRT) with a nicotine patch was more effective in smoking cessation than varenicline alone.Source: Koegelenberg CFN, Noor F, Bateman ED, et al. Efficacy of varenicline combined with nicotine replacement therapy vs. varenicline alone for smoking cessation. A randomized clinical trial. JAMA. 2014;312:155–161. (Source: Clinical Pulmonary Medicine)

Benzodiazepines in the ICU: Enough Is Enough!

Synopsis: In a review of a large intensive care unit (ICU) database, the use of propofol versus benzodiazepines for sedation was associated with lower mortality.Source: Lonardo NW, Mone MC, Nirula R, et al. Propofol is associated with improved outcomes compared with benzodiazepines in ventilated intensive care unit patients. Am J Respir Crit Care Med. 2014;189:1383–1394. (Source: Clinical Pulmonary Medicine)

Evaluation of the new IASLC/ATS/ERS proposed classification of adenocarcinoma based on lepidic pattern in patients with pathological stage IA pulmonary adenocarcinoma

Conclusions This study validated the proposed IASLC/ATS/ERS classification for pulmonary adenocarcinoma in patients with pathological stage IA pulmonary adenocarcinoma. The difference between AIS and IA may depend on the proliferation of the carcinoma. In addition, the difference between VIA and the other adenocarcinoma types may depend on genetic factors, especially K-ras mutations. (Source: General Thoracic and Cardiovascular Surgery)

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