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Sleep disordered breathing and metabolic comorbidities across sex and menopausal status in East Asians: the Nagahama Study

  • Author contributions: Study design: T. Matsumoto and K. Chin; data collection: T. Matsumoto, K. Murase, Y. Tabara, T. Minami, O. Kanai, H. Takeyama, N. Takahashi, S. Hamada, K. Tanizawa, T. Wakamura,

    • Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease

    Implications for the development of novel therapies

    Due to the strong and dynamic interdependency between host and microbiome in local niches, it is unsurprising that most drugs used in clinical practice

    A major genetic determinant of autoimmune diseases is associated with the presence of autoantibodies in hypersensitivity pneumonitis

    Discussion

    Studies about hypersensitivity pneumonitis genetic susceptibility are limited, but HLA class II genes have been identified as critical factors that contribute to disease development [8, 9, 20].

    In the past

    Assessment of Global Lung Function Initiative (GLI) reference equations for diffusing capacity in relation to respiratory burden in the Swedish CArdioPulmonary bioImage Study (SCAPIS)

    Abstract

    The Global Lung Function Initiative (GLI) has recently published international reference values for diffusing capacity of the lung for carbon monoxide (DLCO). Lower limit of normal (LLN), i.e. the 5th

    Minimal clinically important differences in average, best, worst and current intensity and unpleasantness of chronic breathlessness

    Conclusion An improvement of ∼10 mm on a 100-mm VAS is likely to be clinically meaningful across commonly used measures of chronic breathlessness (current intensity, unpleasantness, and average, best and worst intensity

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