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The proportion of lung cancer patients attending UK lung cancer clinics who would have been eligible for low-dose CT screening

Extract

The National Lung Screening Trial (NLST) demonstrated that low-dose computed tomography (LDCT) screening reduced lung cancer mortality by 20% [1]. Lung cancer screening was subsequently recommended by the US Preventive

Oxygen in patients with fibrotic interstitial lung disease: an international Delphi survey

In this study, our expert panel achieved consensus on 20 items that can be used to guide supplemental oxygen use in patients with fibrotic ILD. We further identified several areas where respondents were unsure or where consensus could not be met, suggesting future areas where research efforts should be focused. Finally, we identified discrepancies between scenarios where clinicians would recommend oxygen and poor patient access, based on regional funding criteria or testing requirements.

Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network

Abstract

Although broad knowledge of influenza viral pneumonia has been established, the significance of non-influenza respiratory viruses in community-acquired pneumonia (CAP) and their impact on clinical outcomes remains unclear, especially in

IL-4 subverts mycobacterial containment in Mycobacterium tuberculosis-infected human macrophages

Abstract

Protective immunity against Mycobacterium tuberculosis is poorly understood. The role of interleukin (IL)-4, the archetypal T-helper type 2 (Th2) cytokine, in the immunopathogenesis of human tuberculosis remains unclear.

Blood and/or

Cost-effectiveness of intrapleural use of tissue plasminogen activator and DNase in pleural infection: evidence from the MIST2 randomised controlled trial

The MIST2 (Second Multicentre Intrapleural Sepsis Trial) trial showed that combined intrapleural use of tissue plasminogen activator (t-PA) and recombinant human DNase was effective when compared with single agents or

Nanoparticle diffusion in spontaneously expectorated sputum as a biophysical tool to probe disease severity in COPD

  • Conflict of interest: R. Wise reports grants and personal fees for data monitoring committee work and consultancy from AstraZeneca/Medimmune and GSK, grants and personal fees for data monitoring and steering committee work