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Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis

Vitamin D3 (VD3) is a steroid hormone that regulates bone health and numerous aspects of immune function and may play a role in respiratory health. We hypothesized that T helper type 2 (Th2) disorders, chronic rhinosinusitis with nasal polyps (CRSwNP) and allergic fungal rhinosinusitis (AFRS) would have VD3 deficiencies, resulting in increased mature dendritic cells (DCs) and bone erosion.

We conducted a retrospective study examining VD3 levels in patients with AFRS (n = 14), CRSwNP (n = 9), chronic rhinosinusitis without nasal polyps (CRSsNP) (n = 20) and cerebrospinal fluid leak repair (non‐diseased controls) (n = 14) at time of surgery. Circulating immune cell levels were determined by immunostaining and flow cytometric analysis. Plasma VD3 and immune regulatory...

Clinical Experience on the Treatment of Lung and Liver Lesions with Stereotactic Body Radiotherapy using a Novalis Exactrac Adaptive Gating Technique

Gating techniques can improve the accuracy of the treatment of lung and liver lesions with SBRT, by monitoring organ tumor motion and irradiating within a selected area of the respiratory cycle.

Development of a Dynamic Phantom for Validation of 4D Imaging and Radiotherapy Treatment Delivery

Respiratory-induced motion presents difficulties for the treatment of thoracic tumours with radiotherapy. The introduction of complex, highly modulated treatment modalities for lung cancer patients requires thorough verification to establish confidence in the technique.

The phantom used should be anatomically realistic, possess similar radiological properties to the tissues concerned and contain a tumour-equivalent inclusion that is capable of realistic reproducible motion and that can accommodate a radiation detector.

Foreign body aspiration in children: diagnostic and therapeutic role of bronchoscopy

Conclusions  Aspiration of foreign body should be suspected in all cases of bronchopulmonary infection with atypical course. Bronchoscopy is the best diagnostic and therapeutic method in all suspicions of foreign body. In children rigid bronchoscopy is still the method of choice.

Effect of corticosteroids on the clinical course of community-acquired pneumonia: a randomized controlled trial

Conclusions: MPDN treatment, in combination with antibiotics, improves respiratory failure and accelerates the timing of clinical resolution of severe CAP needing hospital admission.

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