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Allergen-specific nasal provocation testing: review by the rhinoconjunctivitis committee of the Spanish Society of Allergy and Clinical Immunology.

Specific nasal provocation testing (NPT) consists of eliciting a response from the nasal mucosa by controlled exposure to allergens. It is indicated in the diagnostic confirmation of allergic rhinitis and when discrepancies arise or difficulties exist in the assessment of a patient's medical history and the results of skin and/or serological tests.

The technique is also applied to evaluate sensitivity to the allergen, the efficacy and safety profile of treatment, and in research on the pathophysiological mechanisms of nasal response to allergens. NPT also provides information on the etiology of occupational respi...

Asthma Symptoms, Future Attacks Reduced By Omalizumab

Researchers from Boston University School of Medicine (BUSM), in collaboration with researchers from the Inner City Asthma Consortium, have found that among inner-city children, the drug omalizumab improved asthma control, nearly eliminated seasonal exacerbations and reduced the need for controller medication. These findings appear in the March 17th issue of the New England Journal of Medicine. Guidelines-based treatment of persistent asthma follows a step-wise approach designed to achieve control...

Microparticles help identify early emphysema

Measuring blood levels of endothelial microparticles, which are small vesicles released from activated or apoptotic endothelial cells, may help identify early emphysema, say researchers.

Methylation studies reveal lung cancer chemotherapy sensitivities

Japanese researchers appear to have identified a crucial mechanism in controlling expression of breast cancer resistance protein in lung cancer cells.

Delay in Recognition of Pulmonary Arterial Hypertension: Factors Identified From the REVEAL Registry

Pulmonary arterial hypertension (PAH) is a progressive and fatal disorder. Despite the emergence of effective therapy, PAH is commonly advanced when recognized. One in 5 US patients diagnosed with PAH reported symptoms for >2 years before their disease was recognized. Younger individuals and patients with histories of common respiratory disorders were most likely to experience delayed PAH recognition.

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