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Pemetrexed in malignant pleural mesothelioma and the clinical outcome

Conclusions:  Pemetrexed is beneficial for selected patients, but it has not changed the outcome of the whole MPM population as much as perhaps anticipated. Patient groups with various treatments or symptomatic care only reached survival results comparable to those reported in chemotherapy trials, thus emphasizing the need for better subtyping of mesothelioma and individualising the treatment. (Source: The Clinical Respiratory Journal)

Right Side of Heart Linked to Lung Diseases, Study Finds

Title: Right Side of Heart Linked to Lung Diseases, Study FindsCategory: Health NewsCreated: 6/7/2011 2:06:00 PMLast Editorial Review: 6/8/2011 (Source: MedicineNet Lungs General)

Improvement of Cognitive Function After a Three-Month Pulmonary Rehabilitation Program for COPD Patients

The objective of the study was to evaluate the effect of multidisciplinary pulmonary rehabilitation program on cognitive function in COPD patients, adjusting for potential confounders (gender, age, tobacco consumption, and educational level). In this prospective study, 34 COPD patients were submitted to neuropsychological testing before and after a 3-month pulmonary rehabilitation program. A control group with 18 healthy subjects of similar age, sex, and educational status was used to compare the cognitive function of COPD patients and healthy subjects at baseline. The association between the rehabilitation and change on th scores of cognitive variables, adjusted for each covariate, was estimated by means of linear random-intercept regression models. At baseline, the COPD patients ha...

The Efficacy of Chest Radiographs to Detect Parapneumonic Effusions

Conclusions: All three CXR views missed effusions of a size significant enough to warrant thoracentesis. Consideration should be given to obtaining additional imaging at the time patients present with pneumonia, particularly in those with lower lobe consolidation. (Source: Respirology)

Fibrocytes and the tissue niche in lung repair

Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes, hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue niche is important because it modulates the fibrocytes and coordinates their role in tissue behaviour and repair. However, plasticity of a niche may be co-opted in chronic airway diseases such as asthma, idiopathic pulmonary fibrosis and obliterative bronchiolitis. This review will therefore focus on a possible role of fibrocytes in pathological tissue repair processes in those diseases. (Source: Res...

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