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Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy

Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), continue to be a major cause of morbidity and mortality in critically ill patients. The present therapeutic strategies for ALI/ARDS including supportive care, pharmacological treatments, and ventilator support are still controversial. More scientists are focusing on therapies involving stem cells, which have self-renewing capabilities and differentiate into multiple cell lineages, and, genomics therapy which has the potential to upregulate expression of anti-inflammatory mediators. Recently, the combination of cell and gene therapy which has been demonstrated to provide add...

World Heart Federation and the UN High-Level Meeting on Non-Communicable Diseases (NCDs): Advocacy and action to address the global burden of cardiovascular and other NCDs

In September, organizations that have been addressing the four main non-communicable diseases (NCDs), which include cardiovascular disease, cancer, diabetes and chronic respiratory disease, will see the issue of NCDs finally receive focus as a global development issue. The United Nations High-Level Meeting (UN HLM) on the Prevention and Control of Non-communicable Diseases will occur just before the General Assembly and will bring together heads of state and heads of government and their designees for a meeting that, over the course of 2days, will address solutions to the pandemic of NCDs in low-, middle- and high-income countries. The call for this meeting, only the second of its type to address a health issue (the first was the UN General Assembly Special Session on HIV/AIDs in 2001, whi...

Study Highlights Respiratory Disorders Prevalent In The Middle East

Lung diseases in the Middle East range from the centuries-old pulmonary tuberculosis (TB) to modern manifestations caused by chemical warfare. A new paper now available in Respirology, a journal of the Asian Pacific Society of Respirology, provides pulmonologists and patients with the first comprehensive review of respiratory illnesses specific to the Persian Gulf region, and the challenges in treating them. This unique review is the first of its kind in this topic and will serve as an important landmark reference article... (Source: Health News from Medical News Today)

Evidence for phenotype-driven treatment in asthmatic patients

Gonem S, Desai D, Siddiqui S, Brightling CC (Source: The Aspergillus Website - articles)

Seasonality and determinants of moderate and severe COPD exacerbations in the TORCH study.

Seasonality and determinants of moderate and severe COPD exacerbations in the TORCH study.

Eur Respir J. 2011 Jul 7;

Authors: Jenkins CR, Celli B, Anderson JA, Ferguson GT, Jones PW, Vestbo J, Yates JC, Calverley PM

We investigated the impact of season relative to other determinants of chronic obstructive pulmonary disease (COPD) exacerbation frequency in a long-term international study of patients with FEV1 <60% predicted. COPD exacerbations were defined by worsening symptoms requiring systemic corticosteroids and/or antibiotics (moderate) or hospital admission (severe). Seasonality effect was calculated as the proportion of patients experiencing an exacerbation each month Exacerbations in the Northern and Southern regions showed an almost two-fold increase in the winter months. No seasonal pattern occurred in the Tropics. Overall, 38% of exacerbations were treated with antibiotics only, 19% with systemic corticosteroids only and 43% with both, while 20% required hospital admission irrespective of the season. Exacerbation frequency was associated with older age, lower body mass index, lower FEV1 %predicted, and history of prior exacerbations. Females and patients with worse baseline breathlessness by MRC score exacerbated more often (rate ratio (RR) male versus female 0.7, 95% confidence interval (CI): 0.7, 0.8; p<0.001; RR MRC dyspnoea grade 3 versus 1+2 combined 1.1, 95% CI: 1.1, 1.2; p<0.001). The effect of season was independent of these risk factors. COPD exacerbations and hospitalisations are more frequent in winter.

PMID: 21737561 [PubMed - as supplied by publisher]

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