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Surfactant protein A is defective in abrogating inflammation in asthma

Surfactant protein A (SP-A) regulates a variety of immune cell functions. We determined the ability of SP-A derived from normal and asthmatic subjects to modulate the inflammatory response elicited by Mycoplasma pneumoniae, a pathogen known to exacerbate asthma. Fourteen asthmatic and 10 normal control subjects underwent bronchoscopy with airway brushing and bronchoalveolar lavage (BAL). Total SP-A was extracted from BAL. The ratio of SP-A1 to total SP-A (SP-A1/SP-A) and the binding of total SP-A to M. pneumoniae membranes were determined. Airway epithelial cells from subjects were exposed to either normal or asthmatic SP-A before exposure to M. pneumoniae. IL-8 protein and MUC5AC mRNA were measured. Total BAL SP-A concentration did not differ between groups, but the percentage SP-A1 was s...

Clinical Characteristics and Prognosis of Nontuberculous Mycobacterial Lung Disease with Different Radiographic Patterns

Conclusion  In Taiwan, NTM-LD patients with consolidative pattern have the worst prognosis while patients with cavitary pattern have worse survival than those with bronchiectasis in MAC-LD. Because varying radiographic patterns represent different prognoses, understanding the characteristics of NTM-LD patients with different radiographic patterns complements clinical practice. Content Type Journal ArticlePages 1-8DOI 10.1007/s00408-011-9321-4Authors Chin-Chung Shu, Department of Traumatology, Taiwan University Hospital, Taipei, TaiwanChih-Hsin Lee, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei Branch, No. 289, Jianguo Road, Xindian District, New Taipei City, 231 TaiwanChia-Lin Hsu, Department of Internal Medicine, National Taiwan Universi...

High‐sensitivity C reactive protein as a biomarker for grading of childhood asthma in relation to clinical classification, induced sputum cellularity, and spirometry

ConclusionsDespite that pulmonary function tests and clinical classification are the gold standard for grading of asthma, hs‐CRP can be considered as a new marker for assessment of different grades of asthma severity and control. It can be used for indirect detection and monitoring of airway inflammation, disease severity, and response to steroid treatment in asthmatic children. Pediatr Pulmonol. © 2011 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)

The feasibility and safety of Fiberoptic Bronchoscopy during Nonivasive Ventilation in patients with established Acute Lung Injury: another small brick in the wall.

In hypoxemic patients needing fiberoptic bronchoscopy (FOB), noninvasive ventilation (NIV) has been used to prevent gas-exchange deterioration associated with FB, compensate for the increase in work of breathing occurring during FB, thus avoiding endotracheal intubation and its related complications. The application of NIV to allow FOB has been found of particular interest in the diagnosis of pneumonia in patients spontaneously breathing and who started NIV to assist FOB.In patients who were already receiving NIV for acute respiratory failure and who were scheduled to perform FOB, there were less information. In this issue of Critical Care, the study by Baumann and colleagues adds new information to this specific issue, addressing the feasibility and safety of FOB during NIV in patients wi...

School Absenteeism Among Children Living With Smokers

Tobacco smoke exposure leads to respiratory illnesses in children. Geographically and demographically limited studies have suggested a link between living with a smoker and school absenteeism. In a nationally representative sample, we established that absenteeism among children aged 6 to 11 years living with smokers could be reduced 24% to 34% by eliminating smoking in their homes. Caregivers' lost wages/time due to child absenteeism was valued at $227 million per year. (Read the full article) (Source: PEDIATRICS)

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