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Comparison of inhaled corticosteroids and leukotriene receptor antagonists in adolescents and adults with mild to moderate asthma: a meta‐analysis

Conclusion:  Twenty‐four trials with 6197 randomized adolescents and adults with mild to moderate asthma met the inclusion criteria with a minimum duration of 4 weeks' treatment. Significant differences favouring ICS were found in all indices of pulmonary function. Other significant benefits of ICS were shown in symptoms, nocturnal awakenings, rescue‐medication use, symptom‐free days and quality of life. As to each special symptom of adverse effects, ICS was similar to LTRA in the incidence of headache, nausea and throat discomfort, but significantly higher in the incidence of hoarseness and oral pharyngeal candidiasis. Concerning withdrawal because of adverse events potentially related to treatment, ICS was similar to LTRA but significantly superior to LTRA in decreasing the asthm...

The Safety of sputum induction in adults with acute exacerbation of COPD

Conclusions:  SI can be safely and successfully performed in patients with moderate‐to‐very severe COPD who experience an exacerbation using this modified induction protocol. The early decrease in FEV1 can be used to predict the maximum fall.© 2012 Blackwell Publishing Ltd

The effect of mold sensitization and humidity upon allergic asthma

Conclusion:  Mold sensitization is highly associated with more severe asthma while humidity is more of an exacerbating factor in patients with allergic asthma as compared to allergic rhinitis alone. Further delineation between mold sensitization and humidity is needed to determine whether these are independent factors in asthma.© 2012 Blackwell Publishing Ltd

The value of positron emission tomography in early detection of lung cancer in high‐risk population: a systematic review

Conclusions:  PET or PET/CT may be used as a useful tool for early detection of lung cancer in high‐risk population based on the existing information. However, there is still limited information with regards to evidence of survival benefits from PET screening in high‐risk patients.

Radiofrequency ablation for stage I non-small cell lung cancer: management of locoregional recurrence.

Radiofrequency ablation for stage I non-small cell lung cancer: management of locoregional recurrence.

Ann Thorac Surg. 2012 Mar;93(3):921-7; discussion 927-88

Authors: Lanuti M, Sharma A, Willers H, Digumarthy SR, Mathisen DJ, Shepard JA

Abstract
BACKGROUND: This study characterizes the management of locoregional recurrence (LRR) in patients with high-risk stage I non-small cell lung cancer (NSCLC) treated with lung radiofrequency ablation (RFA).
METHODS: Consecutive patients with biopsy-proven stage I NSCLC underwent computed tomography-guided lung RFA from December 2003 to 2010. All patients were deemed medically inoperable or refused an operation. RFA was performed with curative intent.
RESULTS: Fifty-five ablations were performed in 45 patients (age, 51 to 89 years) with stage I NSCLC. At a median follow-up of 32 months, LRR occurred in 21 (38%) within a mean of 12±10 (range, 1-44) months from RFA. Recurrence was observed locally in the tumor bed in 18 (33%), in regional nodes in 4 (7%), and distant in 2 (4%). The mean maximal tumor diameter was 2.3±1.3 (range, 0.7 to 4.5) cm. In tumors exceeding 3 cm, 10 (80%) were associated with LRR. Recurrent lesions were treated with repeat RFA (5), radiotherapy (8), chemoradiotherapy (5), and chemotherapy (2). Local control was achieved by repeat RFA in 2 of 5 (40%) or by radiotherapy in 8 lesions (100%), with 2 regional nodal failures (median follow-up, 40±13 months). Overall survival among patients who did or did not experience LRR was similar (32% to 35%). Repeat RFA was not associated with any significant complications or procedure-related 30-day mortality.
CONCLUSIONS: Lung RFA is associated with increased rates of local failure in tumors exceeding 3 cm and in contact with larger segmental vessels. Patients with local failure can be promptly salvaged with SBRT or repeat RFA, without detriment to overall survival.

PMID: 22296982 [PubMed - indexed for MEDLINE]

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