ConclusionsThis study highlights the influence of age on phenotypes of incident pulmonary arterial hypertension and has shown the changes in demographics and epidemiology over the past decade in a national setting. The results suggest that there may be two subtypes of patients: the younger subtype with more severe haemodynamic impairment but better survival compared with the older subtype who have more comorbidities. PMID: 22798320 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

CONCLUSION: BHR at 10 years was a significant but modest predictor of active asthma six years later with methacholine challenge being superior to exercise test. PMID: 22798318 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

Authors: Mizgerd JP Abstract Acute lower respiratory tract infection is responsible for an inordinate disease burden. Pulmonary immunity determines the outcomes of these infections. The innate and adaptive immune responses to microbes in the lung are critical to maintaining a healthy respiratory system and to preventing pulmonary disease. In addition to balancing antimicrobial defense against the risk of lung injury during the immediate infection, the shaping of pulmonary immunity by respiratory infection contributes to the pathophysiology of many and even perhaps most chronic pulmonary diseases. This Perspective aims to communicate 2 inter-connected points. First, tremendous morbidity and mortality result from inadequate, misguided, or excessive pulmonary immunity. Second, our und...

CONCLUSION: In asthmatic children treated with inhaled corticosteroids, vitamin D deficiency is associated with poorer lung function than children with vitamin D insufficiency or sufficiency. PMID: 22798322 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)