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Efficacy of antibiotic therapy for acute exacerbations of mild to moderate COPD: RCT

Source: American Journal of Respiratory and Critical Care Medicine Area: News Antimicrobial therapy remains a controversial issue in non-severe exacerbations of chronic obstructive pulmonary disease (COPD). This RCT evaluated the efficacy of antibiotic therapy in moderate exacerbations of mild-to-moderate COPD.   The study conducted at 13 centres in Catalonia involved patients aged ?40, smokers or ex-smokers of ten packs-year or more, with forced expiratory volume in one second (FEV1) > 50% predicted and FEV1/ forced vital capacity ratio < 0.7, who were diagnosed with an exacerbation. They were randomised to receive either amoxicillin/ clavulanate 500/125 mg or placebo TDS for 8 days. The primary outcome measure was clinical cure at end of therapy visit (EOT) at days 9-11...

Efficacy of once-daily COPD portfolio versus comparators

Further data from the Novartis once-daily chronic obstructive pulmonary disease (COPD) clinical trial programs has been presented at the European Respiratory Society (ERS) Congress. Overall, Novartis presented 14 abstracts, including data from the investigational QVA149 (fixed-dose combination of indacaterol maleate/glycopyrronium bromide) IGNITE Phase III clinical trial programme, the glycopyrronium bromide (Seebri® Breezhaler®) GLOW Phase III clinical trial programme and the indacaterol maleate (Onbrez® Breezhaler®) INERGIZE Phase III/IV clinical trial programme. (Source: Pharmacy Europe)

Beta-blocker use and COPD mortality: a systematic review and meta-analysis

Conclusion: The results of this review are consistent with a protective effect of beta-blockers with respect to all cause mortality. Due to the observational nature of the included studies, the possibility of confounding that may have affected these results cannot be excluded. The hypothesis that beta blocker therapy might be of benefit in COPD needs to be evaluated in randomised controlled trials. (Source: BMC Pulmonary Medicine - Latest articles)

Breathable Treatment To Help Prevent Asthma Attacks

Details of a treatment that could help asthmatics fight infections that trigger 80% of asthma attacks, developed by University of Southampton spin-out company Synairgen, was presented to European respiratory experts on Sunday 2 September. The study provides the first evidence that boosting asthmatics' immune systems can help reduce the number of asthma attacks due to the common cold and other viral infections for the 5.4 million asthmatics in the UK... (Source: Health News from Medical News Today)

e-Cigarettes Can Damage The Lungs: Warning From Experts

New research has shown that despite electronic cigarettes being marketed as a potentially safer alternative to normal cigarettes, they are still causing harm to the lungs. A new study, presented at the European Respiratory Society's Annual Congress in Vienna, has added new evidence to the debate over the safety of alternative nicotine-delivery products. Electronic cigarettes are devices that deliver nicotine through a vapour, rather than smoke. There is no combustion involved but the nicotine in the device is still derived from tobacco... (Source: Health News from Medical News Today)

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