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Endometriosis of the lung: report of a case and literature review.

Eur J Med Res. 2013;18:13

Authors: Huang H, Li C, Zarogoulidis P, Darwiche K, Machairiotis N, Yang L, Simoff M, Celis E, Zhao T, Zarogoulidis K, Katsikogiannis N, Hohenforst-Schmidt W, Li Q

Abstract
This paper reports a case of endometriosis of the lung in a 29-year-old woman with long-term periodic catamenial hemoptysis. A chest computed tomography image obtained during menstruation revealed a radiographic opaque lesion in the lingular segment of the left superior lobe. During bronchoscopy, bleeding in the mucosa of the distal bronchus of the lingular segment of the left superior lobe was observed. Histopathology subsequent to an exploratory thoracotomy confirmed the diagnosis of endometriosis of the left lung. The 2-year follow-up after lingular lobectomy of the left superior lobe showed no recurrence or complications.

PMID: 23634803 [PubMed - in process]

Reduced port video-assisted thoracoscopic surgery using a needle scope for lung and mediastinal lesions.

Interact Cardiovasc Thorac Surg. 2013 May 3;

Authors: Kaga K, Hida Y, Nakada-Kubota R, Ohtaka K, Muto J, Ishikawa K, Kato T, Matsui Y

Abstract
OBJECTIVESThere are many recent and minimally invasive surgical innovations, yet there has been little evaluation of the limitations of such techniques, particularly those related to video-assisted thoracoscopic surgery. The aims of this study were to determine the usefulness and limitations of video-assisted thoracoscopic surgery using one-port access and needle scope and to evaluate the feasibility of this procedure based on our institutional experience.METHODSThis retrospective study involved 127 patients who underwent video-assisted thoracoscopic surgery using the one-window and puncture method at our institute from 1997 to 2011. One hundred patients underwent surgical treatment and 27 underwent diagnostic procedures. If there was one lesion present with only mild adhesion that did not require lymph node dissection, we decided to opt for the one-direction approach that provisionally indicates the one-window and puncture method. We compared the conversion and success groups for factors like age, sex, laterality of surgery, objective of surgery, target organ and surgery location.RESULTSOf 127 cases, 115 (91%) successfully underwent the one-window and puncture procedure. Twelve cases (9%) were converted to the two-window method or thoracotomy. Compared with those targeting the lung, patients with mediastinal lesions demonstrated a higher tendency for conversion (P < 0.05). However, age (P = 0.89), sex (P = 0.46), laterality of surgery (P = 0.34) and purpose of surgery (P = 0.68) did not show any significant differences between the groups.CONCLUSIONSFor lung and mediastinal diseases, video-assisted thoracoscopic surgery with the one-window and puncture method can be performed at any location (upper, middle and lower lobe of lung and anterior, middle and posterior of the mediastinum) under limited indications that include the possibility of one-way resection, mild adhesion and no requirement of lymph node dissection. Under provisional criteria, the procedure may be feasible.

PMID: 23644732 [PubMed - as supplied by publisher]

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Does hydatid disease have protective effects against lung cancer?

Mol Biol Rep. 2013 May 5;

Authors: Karadayi S, Arslan S, Sumer Z, Turan M, Sumer H, Karadayi K

Abstract
We hypothesized that solid tumors rarely occur in patients with hydatid disease. We obtained the serum of 14 patients diagnosed with hydatid disease, the serum of 10 patients who did not have a history of hydatid disease, and the hydatid cyst fluid from six patients. These sera and fluid samples were added at different concentrations to NCI-H209/An1 human lung small cell carcinoma cells and L929 mouse fibroblasts as a control group. Sera of patients with hydatid diseases had cytotoxic effects on NCI-H209/An1 cells, but they did not have cytotoxic effects on fibroblast cells. Sera from healthy subjects did not have a cytotoxic effect on the tumor cell line or control fibroblasts. Cyst fluid, also, did not have toxic effects on the NCI-H209/An1 cell line, but was toxic to fibroblasts up to a 1:32 dilution. Sera from patients with hydatid disease had cytotoxic effects on human small cell lung cancer cells in vitro.

PMID: 23645038 [PubMed - as supplied by publisher]

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Adult stem cells for chronic lung diseases.

Respirology. 2013 May 7;

Authors: Mora AL, Rojas M

Abstract
Idiopathic pulmonary fibrosis (IPF) and Chronic Obstructive Pulmonary Disease (COPD) are chronic, progressive and lethal lung diseases. The incidence of IPF and COPD increases with age, independent of exposure to common environmental risk factors. At present, there is limited understanding of the relationship between aging and the development of chronic lung diseases. One hypothesis is that chronic injury drives to exhaustion the local and systemic repair responses in the lung. These changes are accentuated during aging where there is a progressive accumulation of senescent cells. Recently, stem cells have emerged as a critical reparative mechanism for lung injury. In this review, we discuss the repair response of bone marrow derived mesenchymal stem cells (B-MSCs) after lung injury and how their function is affected by aging. Our own work has demonstrated a protective role of B-MSCs in several animal models of acute and chronic lung injury. We recently demonstrated the association, using animal models, between age and an increase in the susceptibility to develop severe injury and fibrosis. At the same time, we have identified functional differences between B-MSCs isolated from young and old animals. Further studies are required to understand the functional impairment of aging B-MSCs, ultimately leading to a rapid stem cell depletion or fatigue, interfering with their ability to play a protective role in lung injury. The elucidation of these events will help in the development of rational and new therapeutic strategies for COPD and IPF.

PMID: 23648014 [PubMed - as supplied by publisher]