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Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Diseases: Comprehensive Review of the Recent Literature 2010-2012.

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Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Diseases: Comprehensive Review of the Recent Literature 2010-2012.

Ann Am Thorac Soc. 2013 Jul 19;

Authors: Weiss DJ

Abstract
A conference, "Stem Cells and Cell Therapies in Lung Biology and Lung Diseases", was held July 25-28, 2011 at the University of Vermont, to review the current understanding of the role of stem and progenitor cells in lung repair after injury and to review the current status of cell therapy and ex vivo bioengineering approaches for lung diseases. These are rapidly expanding areas of study that both provide further insight into and challenge traditional views of mechanisms of lung repair after injury and pathogenesis of several lung diseases. The goals of the conference were to summarize the current state of the field, discuss and debate current controversies, and to identify future research directions and opportunities for both basic and translational research in cell based therapies for lung diseases. The goal of this article, which accompanies the formal conference report, is to provide a comprehensive review of the published literature in lung regenerative medicine from the last conference report through December 2012.

PMID: 23869446 [PubMed - as supplied by publisher]

Update on the diagnosis and classification of ILD.

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Update on the diagnosis and classification of ILD.

Curr Opin Pulm Med. 2013 Jul 18;

Authors: Ryerson CJ, Collard HR

Abstract
PURPOSE OF REVIEW: The purpose of this review is to provide an update on the diagnosis and classification of interstitial lung disease (ILD), with a specific focus on newly described ILD subtypes and phenotypes. In addition, the strengths and limitations of the current approach to ILD diagnosis and management are discussed.
RECENT FINDINGS: Idiopathic pleuroparenchymal fibroelastosis and acute fibrinous and organizing pneumonia are new entities that have been described in small case series. Undifferentiated connective tissue disease-associated ILD, smoking-related interstitial fibrosis, familial ILD, unclassifiable ILD, and subclinical ILD have also been better characterized in recent publications. New data regarding these conditions are summarized in this review. The multidisciplinary approach to ILD is reviewed, and complementary classification schemes are described that may help direct the management and improve prognostication of some ILDs.
SUMMARY: ILDs are a large and heterogeneous group of diseases with several newly characterized subtypes and phenotypes. The current approach to ILD classification has limitations in some patients that can be minimized by considering complementary classification schemes.

PMID: 23872860 [PubMed - as supplied by publisher]

Coronavirus Is Not Global Emergency: WHO Committee

The Middle East respiratory syndrome coronavirus (MERS) is not a "public health emergency of international concern", the emergency committee of the World Health Organization said on Wednesday.Source: Reuters Health Related MedlinePlus Pages: Coronavirus Infections, International Health (Source: MedlinePlus Health News)

The International Multidisciplinary Classification of Lung Adenocarcinoma 
from IASLC/ATS/ERS and Problems in Clinical Practice

The international multidisciplinary classification of lung adenocarcinoma sponsored by International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society in 2011, addresses the classification which is appropriate for resection specimens, small biopsies and cytology, respectively for the first time. For resection specimens, new concepts are introduced such as adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA); Invasive adenocarcinomas are recommended to be classified by comprehensive histologic pattern. During the clinical practice, pathologists and clinicians have some confusions in understanding and application of to the new guideline to some extent. This paper will interpret this new guideline, discuss and analyze the issue...

Are you worried about the MERS Virus? Get the facts first…

You may have seen some pretty scary headlines in recent days relating to a new virus that has the medical community on alert. Middle East Respiratory Syndrome (MERS) is a viral respiratory illness that can be passed between people in close contact. The condition was first reported in 2012 in Saudi Arabia, and so far most of those who have been infected have been from that region of the world.   People with MERS develop severe acute respiratory illness, presenting symptoms like fever, coughing and shortness of breath. About half of the 81 reported cases— mostly older men with pre-existing health conditions—have died. However, other cases have been reported where the patient experienced just mild respiratory illness.   While MERS is not the same as the SARS virus, it has similar attr...

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