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A meta‐analysis: Is low‐dose computed tomography a superior method for risky lung cancers screening population?

ConclusionAmong the risky population, LDCT screening find out more stage I lung cancers and total lung cancers, compared with Chest X‐ray or no screening, and also shows advantages in decreasing lung cancer‐specific mortality, but the screening method does not decrease all cause mortality and have a higher false‐positive rates in diagnosis. (Source: The Clinical Respiratory Journal)

Delays for diagnosis and treatment of lung cancers: a systematic review

The impact of diagnosis and treatment delays for non‐small cell lung cancer (NSCLC) management is poorly understood, even if the literature on the subject is currently increasing in importance.

We have few indicators which can serve as reference for quality assurance actions. Several studies analyzed these delays mostly in a monocentric setting. There is an important variability in the definition of these delays, in the collection methods, and in the results obtained. However, it seems distinctly clear that long delays are frequently observed in less symptomatic patients and, therefore, are accompanied by better prognosis.

More standardized definitions and procedures to calculate time intervals between cancer diagnosis and treatment should be implemented to better understand the...

See How Ebola’s Spread Compares to Other Deadly Outbreaks

ebolaWhen the director of the Centers for Disease Control and Prevention (CDC) compared Ebola to AIDS last week, he introduced a new note of urgency to the outbreak. As was the case in the early days of HIV, there are currently no approved drugs to treat Ebola, and the virus carries the potential to cause untold devastation—not to mention a lot of panic.

But as an epidemic, Ebola has far more in common with other diseases. Here’s a comparison of Ebola’s impact over the past 19 weeks to other recent outbreaks that, like Ebola, have no known cure or vaccine. Middle East Respiratory Syndrome (MERS) MERS is a viral respiratory illness first reported in Saudi Arabia in September 2012.

The World Health Organization has since reported 853 MERS infections, of which at least 301 were ...

Pathogenesis of Middle East respiratory syndrome coronavirus

This article reviews the clinical and pathological available on MERS and compares it to SARS. Most importantly, chest radiographs and imaging results of patients with MERS show features that resemble the findings of organizing pneumonia, different from the lesions in SARS patients, which show fibrocellular intra‐alveolar organization with a bronchiolitis obliterans organizing pneumonia‐like pattern. These findings are in line with differences in the induction of cytopathological changes, induction of host gene responses and sensitivity to the antiviral effect of interferons in vitro when comparing both MERS‐CoV and SARS‐CoV. The challenge will be to translate these findings into an integrated picture of MERS pathogenesis in humans and to develop intervention strategies that eventua...

Obstructive Sleep Apnea During REM Sleep and Hypertension: Results of the Wisconsin Sleep Cohort.

Conclusions: Our findings indicate that REM OSA is cross-sectionally and longitudinally associated with hypertension. This is clinically relevant since treatment of OSA is often limited to the first half of the sleep period leaving most of REM sleep untreated. PMID: 25295854 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

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