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Minimal clinically important differences in average, best, worst and current intensity and unpleasantness of chronic breathlessness

Conclusion An improvement of ∼10 mm on a 100-mm VAS is likely to be clinically meaningful across commonly used measures of chronic breathlessness (current intensity, unpleasantness, and average, best and worst intensity

A major genetic determinant of autoimmune diseases is associated with the presence of autoantibodies in hypersensitivity pneumonitis

Discussion

Studies about hypersensitivity pneumonitis genetic susceptibility are limited, but HLA class II genes have been identified as critical factors that contribute to disease development [8, 9, 20].

In the past

Quality of life, tuberculosis and treatment outcome; a case-control and nested cohort study

Discussion

The EUROHIS-QOL eight-item questionnaire was a valid instrument to measure general QOL in TB-affected people. It was successfully completed by almost all participants and demonstrated good reliability, validity and responsiveness

Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: towards personalised treatment approaches

Abstract

In January 2019, a European Respiratory Society research seminar entitled “Targeting the detrimental effects of sleep disturbances and disorders” was held in Dublin, Ireland. It provided the opportunity to critically

{beta}2-integrin LFA1 mediates airway damage following neutrophil transepithelial migration during respiratory syncytial virus infection

Neutrophil transepithelial migration assay

Primary airway epithelial cells were obtained from nasal brushings, as described previously [21] or purchased from Epithelix Sàrl (Geneva, Switzerland). A diagram of our methodology is shown

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