M-A | Combination therapy with long-acting bronchodilators and risk of adverse cardiovascular events in patients with COPD.
Combination therapy with long-acting bronchodilators and the risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis – European Respiratory Journal (link to abstract – $ for full-text)
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RCT | High-flow nasal cannula oxygen did not reduce mortality in patients with respiratory failure due to COVID-19.
Effect of High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy on Mortality in Patients With Respiratory Failure Due to COVID-19: The SOHO-COVID Randomized Clinical Trial – JAMA (link to abstract – $ for full-text) Commentary: High-Flow Oxygen Fails to Reduce Mortality due to COVID-19 Respiratory Failure – HCP Live
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M-A of randomized trials | High-flow nasal cannula oxygen therapy vs. non-invasive ventilation for patients with acute exacerbation of COPD after extubation.
High-Flow Nasal Cannula Oxygen Therapy versus Non-Invasive Ventilation for AECOPD Patients After Extubation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – International Journal of Chronic Obstructive Pulmonary Disease
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RCT | Dipeptidyl peptidase-1 inhibition does not improve outcomes in patients hospitalized with COVID-19.
Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial – The Lancet Respiratory Medicine Commentary on Twitter NEW Research—Brensocatib treatment did not improve clinical status at day 29 in patients hospitalised with #COVID19 Being presented at #ERSCongress, ALERT 3 session, Sept 5 from 13:15 BST From @profjdchalmers, @keirholly, […]
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RCT | Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19.
Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet Respiratory Medicine Commentaries on Twitter Interesting results in the #PANAMO trial of vilobelimab, an anti-C5a antibody, in critically ill ICU patients w/ COVID19. People on MV (n=386) randomized to […]
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RCT | A double-dose influenza vaccination during hospitalization for acute coronary syndrome did not improve outcomes compared to standard-dose outpatient vaccination.
Influenza vaccination strategy in acute coronary syndromes: the VIP-ACS trial – European Heart Journal Commentary on Twitter In the VIP-ACS trial, among patients hospitalised with an ACS, double dose influenza vaccination before discharge does not reduce cardiovascular and pulmonary outcomes compared with standard dose vaccination ?https://t.co/L9e7MXWfWV#EHJ #ESCCongress @ehj_ed @rladeiraslopes pic.twitter.com/95o50krrwm — European Society of […]
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RCT | Dexamethasone is not effective for the treatment of dyspnea in patients with cancer and increases the risk of adverse events.
Effect of dexamethasone on dyspnoea in patients with cancer (ABCD): a parallel-group, double-blind, randomised, controlled trial – The Lancet Oncology (free for a limited period) Commentary on Twitter Our phase III randomized study, published in Lancet Oncology today, showed high-dose steroid didn’t improve SOB and should not be used routinely in pts with lung […]
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M-A of randomized trials | In patients hospitalized with community-acquired pneumonia, corticosteroids reduce the need for mechanical ventilation without significant effects on mortality, treatment failure, or adverse events.
Effect of corticosteroids on mortality and clinical cure in community-acquired pneumonia: A systematic review, meta-analysis, and meta-regression of randomized control trials – CHEST Journal (link to abstract – $ for full-text) Related: Corticosteroids for CAP, influenza and COVID-19: when, how and benefits or harm? – European Respiratory Review
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The Lancet Commission | Towards the elimination of chronic obstructive pulmonary disease.
Homepage: Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission – The Lancet Commission: Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission Editorial: COPD: from an end-stage disease to lifelong lung health Invited Commentary: Classification of COPD: fostering prevention and precision medicine in the Lancet Commission on COPD Commentary: Proposed classification of COPD according […]
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The Lancet Commission on lessons for the future from the COVID-19 pandemic – “a massive global failure.”
Homepage: The Lancet COVID-19 Commission The Lancet Commission on lessons for the future from the COVID-19 pandemic Editorial: COVID-19: the case for prosociality News Release: New report details “massive global failures” of COVID-19 response, calls for improved multilateral cooperation to end pandemic and effectively manage future global health threats – The Lancet Infographic: COVID-19 response: a massive global failure […]
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