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Managing Cystic Fibrosis: Strategies that Increase Life Expectancy and Improve Quality of Life.

The survival of patients with cystic fibrosis (CF) continues to improve. The discovery and cloning of the CFTR gene over 21 years ago led to the identification of the structure and function of the CFTR chloride channel.

New therapies based on the understanding of the function of CFTR are currently under development. The better clinical status and improved survival of patients with CF is not only a result of understanding of the molecular mechanisms of CF, but also as a result of the development of therapeutic strategies that are based on insights into the natural course of the disease. Current CF treatments that target respiratory infections, inflammation, mucociliary clearance and nutritional status are associated with improved pulmonar...

Determining the appropriate sleeve lobectomy versus pneumonectomy ratio in central non-small cell lung cancer patients: an audit of an aggressive policy of pneumonectomy avoidance [Original articles]

Conclusions: Parenchyma-sparing procedures can reduce the PN rate to less than 10%. A PN:SL index lower than 1:1.5 as a quality standard in a specialised thoracic unit should encourage the use of broncho-angioplastic procedures and improve patient outcomes. Long-term survival, QoL, postoperative lung function test and tolerance of adjuvant therapies are significantly better after SL than PN intervention.

Bronchoscopic lung volume reduction as a bridge to lung transplantation in patients with chronic obstructive pulmonary disease [Original articles]

Conclusions: BLVR allowed to improve the functional status and quality of life of these patients. In a selected group of COPD patients awaiting lung transplantation, the reported short- to medium-term objective improvement may play an important role to ameliorate the clinical status and reach the time of surgery.

Asthma UK Comment On: The New England Journal Of Medicine: Exposure To Environmental Microorganisms And Childhood Asthma

This study adds to evidence supporting the "hygiene hypothesis", which shows that early exposure to potential allergens reduces the risk of asthma and allergy development.

Although research repeatedly links the farming lifestyle with a reduction in asthma and allergies, it is still unclear how this information can be used in prevention strategies, either through vaccines or other methods...

Management of Community-acquired Pneumonia

Community-acquired pneumonia affects approximately 5.6 million patients annually in the US. This paper reviews recent advances in the diagnosis and optimal management of CAP.

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