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Medical Treatment of Mesothelioma: Anything New?

In the present report, we review the current standard and investigational treatments of malignant pleural mesothelioma (MPM). Several studies have reported the use of gemcitabine and cisplatin as an induction chemotherapy in combination with extrapleural pneumonectomy (EPP) and thoracic radiation in a combined-modality approach for resectable MPM.

Since the combination of cisplatin with pemetrexed was applied as the standard first-line regimen for unresectable MPM, the combination as an induction chemotherapy regimen has been proven effective in phase 2 trials. In addition, intensity-modulated radiation therapy and proton therapy have been introduced as new radiation methods into the combined modality. Hyperthermic intraoperative chemotherapy following EPP appears...

Procalcitonin‐guidance for reduction of antibiotic use in low‐risk outpatients with community acquired pneumonia

Conclusions:  Under PCT guidance, antibiotic use was reduced and duration of antibiotic treatment was shortened in low‐risk outpatients with CAP, without apparent harm.

High blood pressure, antihypertensive medication and lung function in a general adult population.

Conclusion: Our analysis indicates that both high blood pressure and the use of beta-blockers, but not the use of other antihypertensive medication, are associated with reduced lung function in a general adult population.

The Cardiovascular and Chronic Diseases Epidemic in Low- and Middle-Income Countries: A Global Health Challenge

In 2009, the world mobilized against the threat of pandemic influenza, which infected close to half a million individuals and killed approximately 15,000 others; however, the world cannot get its act together to tackle chronic diseases that affect hundreds of millions of people worldwide and which, in 2008 alone, killed more than 30 million individuals. Chronic diseases, including cardiovascular diseases (CVD), cancer, diabetes, and chronic respiratory diseases, account for close to one-half of the world's global burden of disease.

It is expected that by 2030, 7 of 10 deaths worldwide will be due to chronic diseases, and CVD will account for the largest share of these deaths. Currently, myocardial infarction and strokes account for approximately 12 million deaths worldwide each year. Al...

Conventional and Novel Approaches to Immunosuppression

Immunosuppressive therapy has contributed significantly to improved survival after solid organ transplantation. Nevertheless, treatment-related adverse events and persistently high risk of chronic graft rejection remain major obstacles to long-term survival after lung transplantation. The development of new agents, refinements in techniques to monitor immunosuppression, and enhanced understanding of transplant immunobiology are essential for further improvements in outcome.

In this article, conventional immunosuppressive regimens, novel approaches to preventing graft rejection, and investigational agents for solid organ transplantation are reviewed.

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