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Potential of Nasopharynx-associated Lymphoid Tissue for Vaccine Responses in the Airways.

Nasopharynx-associated lymphoid tissue (NALT), constituting Waldeyer's ring in humans, is a unique inductive site for B-cell responses and plasma cell (PC) generation. This makes the nasal route of vaccine administration interesting for induction of mucosal and systemic antibodies.

The unpaired nasopharyngeal tonsil (adenoids) and the paired palatine tonsils are prominent NALT structures - functionally similar to the paired rodent NALT structures located dorsal to the cartilaginous soft palate. But human NALT is more strategically located as its elements are exposed to both airborne and alimentary antigens and have antigen-retaining crypts. It also shows similarities with lymph nodes and participates both in systemic-type and secretory-type mucosal immunity. Prima...

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization.

CONCLUSIONS: These data demonstrate that the presence of commensal bacteria is critical for ensuring normal cellular maturation, recruitment and control of allergic airway inflammation.

Abnormal Vocal Cord Function in Difficult-to-Treat Asthma.

CONCLUSIONS: Non-invasive CT larynx quantification of laryngeal movement was achieved employing CT larynx. Significant numbers of patients with difficult-to-treat asthma had excessive narrowing of the vocal cords. This new approach has identified frequent upper airway dysfunction in asthma with potential implications for disease control and treatment.

Nebulized Ceftazidime and Amikacin in Ventilator-associated Pneumonia caused by Pseudomonas Aeruginosa.

CONCLUSION: Nebulization and intravenous infusion of ceftazidime and amikacin provide similar efficiency for treating ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Nebulization is efficient against intermediate strains and may prevent per-treatment acquisition of antibiotic resistance.

Clinical and Radiographic Predictors of GOLD-Unclassified Smokers in COPDGene.

CONCLUSION: Subjects with reduced FEV1 and a preserved FEV1/FVC ratio are a heterogeneous group with significant symptoms and functional limitation who likely have a variety of underlying etiologies beyond increased BMI.

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