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Treatment of pulmonary arterial hypertension with circulating angiogenic cells

In conclusion, CAC therapy was not associated with increased survival and did not result in either clinical or histological benefits. Future studies should be geared toward either earlier therapeutic time points with varying doses of unmodified CACs or genetically modified cells as a means of delivery of factors to the pulmonary arterial circulation. (Source: AJP: Lung Cellular and Molecular Physiology)

Thirdhand smoke: a new dimension to the effects of cigarette smoke on the developing lung

The underlying mechanisms and effector molecules involved in mediating in utero smoke exposure-induced effects on the developing lung are only beginning to be understood. However, the effects of a newly discovered category of smoke, i.e., thirdhand smoke (THS), on the developing lung are completely unknown. We hypothesized that, in addition to nicotine, other components of THS would also affect lung development adversely. Fetal rat lung explants were exposed to nicotine, 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal (NNA), or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), the two main tobacco-specific N-nitrosamine constituents of THS, for 24 h. We then determined key markers for alveolar paracrine signaling [epithelial differentiation markers surfactant phospholipid and prot...

Colonization of Pediatric Lower Respiratory Tract with Genital Mycoplasma Species

Conclusions:  Our data indicate that in addition to M. pneumoniae, urogenital Mycoplasma species may colonize the airway of patients with chronic respiratory diseases. There was however, no association between chronic asthma diagnosis and Mycoplasma colonization in this study. (Source: Respirology)

Implementation of a Multicenter Rapid Response System in Pediatric Academic Hospitals Is Effective

This study from the Ontario Pediatric Critical Care Response Team Collaborative is unique in that it is the first multicenter, prospective, observational study describing the implementation of a pediatric rapid response system using a physician-led medical emergency team. (Read the full article) (Source: PEDIATRICS)

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One Century of Allergen-Specific Immunotherapy for Respiratory AllergyOne Century of Allergen-Specific Immunotherapy for Respiratory Allergy

Accumulating evidence closes in on subcutaneous and sublingual immunotherapy and its central role in the management of respiratory allergy. Immunotherapy (Source: Medscape Today Headlines)

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