Chronic Obstructive Pulmonary Disease Exacerbations: Better Standards – Better Prognosis
Respiration (DOI:10.1159/000329880) (Source: Respiration)
Sté Tunisienne des Maladies Respiratoires et d'Allergologie
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Socioeconomic Status and Health-Related Quality of Life of Patients with Chronic Obstructive Pulmonary Disease
Respiration (DOI:10.1159/000328766) (Source: Respiration)
Pulmonary-renal syndromes: An update for respiratory physicians
Publication year: 2011
Source: Respiratory Medicine, In Press, Corrected Proof, Available online 20 June 2011
Colm, McCabe , Quentin, Jones , Aikaterini, Nikolopoulou , Chris, Wathen , Raashid, Luqmani
Pulmonary-renal syndromes are a group of disorders characterised by necrotising glomerulonephritis and pulmonary haemorrhage. Small vessel systemic vasculitis is the most common cause of pulmonary-renal syndromes presenting to respiratory physicians. Rarer causes include systemic lupus erythematosus and connective tissue diseases though severe pneumonia or cardiac failure may mimic their presentation. Some forms of small vessel vasculitides have a predilection for the pulmonary and renal vascular beds and if left untreated can result in fulminant organ failure. Whilst the aetiology of these syndromes remains unclear, much is known about the disease mechanisms including the pathogenic role of autoantibodies, immune-complex mediated inflammation...
Source: Respiratory Medicine, In Press, Corrected Proof, Available online 20 June 2011
Colm, McCabe , Quentin, Jones , Aikaterini, Nikolopoulou , Chris, Wathen , Raashid, Luqmani
Pulmonary-renal syndromes are a group of disorders characterised by necrotising glomerulonephritis and pulmonary haemorrhage. Small vessel systemic vasculitis is the most common cause of pulmonary-renal syndromes presenting to respiratory physicians. Rarer causes include systemic lupus erythematosus and connective tissue diseases though severe pneumonia or cardiac failure may mimic their presentation. Some forms of small vessel vasculitides have a predilection for the pulmonary and renal vascular beds and if left untreated can result in fulminant organ failure. Whilst the aetiology of these syndromes remains unclear, much is known about the disease mechanisms including the pathogenic role of autoantibodies, immune-complex mediated inflammation...
Effect of fluticasone propionate/salmeterol on arterial stiffness in patients with COPD
Publication year: 2011
Source: Respiratory Medicine, In Press, Corrected Proof, Available online 21 June 2011
Mark T., Dransfield , John R., Cockcroft , Raymond R., Townsend , Harvey O., Coxson , Sanjay S., Sharma , ...
Background: COPD is associated with increased arterial stiffness which may in part explain the cardiovascular morbidity observed in the disease. A causal relationship between arterial stiffness and cardiovascular events has not been established, though their strong association raises the possibility that therapies that reduce arterial stiffness may improve cardiovascular outcomes. Prior studies suggest that fluticasone propionate/salmeterol (FSC) may improve cardiovascular outcomes in COPD and we hypothesized that FSC would reduce arterial stiffness in these patients. Methods: This multicenter, randomized, double-blind, placebo-controlled study compared the effects of FSC 250/50 μg twice-daily and placebo on aortic pulse wave velocity (aPWV) as determined by ECG-gated carotid and...
Source: Respiratory Medicine, In Press, Corrected Proof, Available online 21 June 2011
Mark T., Dransfield , John R., Cockcroft , Raymond R., Townsend , Harvey O., Coxson , Sanjay S., Sharma , ...
Background: COPD is associated with increased arterial stiffness which may in part explain the cardiovascular morbidity observed in the disease. A causal relationship between arterial stiffness and cardiovascular events has not been established, though their strong association raises the possibility that therapies that reduce arterial stiffness may improve cardiovascular outcomes. Prior studies suggest that fluticasone propionate/salmeterol (FSC) may improve cardiovascular outcomes in COPD and we hypothesized that FSC would reduce arterial stiffness in these patients. Methods: This multicenter, randomized, double-blind, placebo-controlled study compared the effects of FSC 250/50 μg twice-daily and placebo on aortic pulse wave velocity (aPWV) as determined by ECG-gated carotid and...
The health, activity, dyspnea, obstruction, age, and hospitalization: Prognostic score for stable COPD patients
Publication year: 2011
Source: Respiratory Medicine, In Press, Corrected Proof, Available online 23 June 2011
Cristóbal, Esteban , José María, Quintana , Myriam, Aburto , Javier, Moraza , Inmaculada, Arostegui , ...
Multidimensional instruments for determining the severity and prognosis of chronic obstructive pulmonary disease (COPD) must be used in daily clinical practice. Objective: To develop and validate a new COPD severity score using variables readily obtained in clinical practice and to compare its predictive capacity with that of other multidimensional indexes.Data collected from a prospective cohort of 611 stable COPD patients were used to derive a clinical prediction rule that was later validated in a separate prospective cohort of 348 patients.In the multivariate analyses, six independent predictive factors were correlated with overall and respiratory mortality: health status, physical activity, dyspnea, airway...
Source: Respiratory Medicine, In Press, Corrected Proof, Available online 23 June 2011
Cristóbal, Esteban , José María, Quintana , Myriam, Aburto , Javier, Moraza , Inmaculada, Arostegui , ...
Multidimensional instruments for determining the severity and prognosis of chronic obstructive pulmonary disease (COPD) must be used in daily clinical practice. Objective: To develop and validate a new COPD severity score using variables readily obtained in clinical practice and to compare its predictive capacity with that of other multidimensional indexes.Data collected from a prospective cohort of 611 stable COPD patients were used to derive a clinical prediction rule that was later validated in a separate prospective cohort of 348 patients.In the multivariate analyses, six independent predictive factors were correlated with overall and respiratory mortality: health status, physical activity, dyspnea, airway...