ABSTRACTLung cancer, of which non‐small cell lung cancer (NSCLC) comprises the majority, is the leading cause of cancer‐related deaths in the United States and worldwide. Lung adenocarcinomas are a major subtype of NSCLCs, are increasing in incidence globally in both males and females and smokers and non‐smokers and are the cause for almost 50% of deaths attributable to lung cancer. Lung adenocarcinoma is a tumor with complex biology that we have recently started to understand with the advent of various histological, transcriptomic, genomic and proteomic technologies. However, the histological and molecular pathogenesis of this malignancy is still largely unknown. This review will describe advances in the molecular pathology of lung adenocarcinoma with emphasis on genomics and DNA al...

AbstractObesity has long been recognized as having significant effects on respiratory function. The topic has been studied for at least the last half century, and some clear patterns have emerged. Obese patients tend to have higher respiratory rates and lower tidal volumes. Total respiratory system compliance is reduced for a variety of reasons, which will be discussed. Lung volumes tend to be decreased, especially expiratory reserve volume (ERV). Spirometry, gas exchange, and airway resistance all tend to be relatively well preserved when adjusted for lung volumes. Patients may be mildly hypoxaemic, possibly due to ventilation‐perfusion mismatching at the base of the lungs, where microatelectasis is likely to occur. Weight loss leads to a reversal of these changes. For all of these chan...

Researchers at Weill Cornell Medical College say they have taken an important step forward in their quest to "turn on" lung regeneration -- an advance that could effectively treat millions of people suffering from respiratory disorders. In the journal Cell, the research team reports that they have uncovered the biochemical signals in mice that trigger generation of new lung alveoli, the numerous, tiny, grape-like sacs within the lung where oxygen exchange takes place... (Source: Health News from Medical News Today)

Conclusion  Indications for a PSG should be handled less restrictively in the diagnostic workup of older insomnia patients since they have a higher risk of comorbid sleep disorders even in the absence of the clinical signs of SAS or PLM. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s11325-011-0608-8Authors Tatjana Crönlein, Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, 93042 Regensburg, GermanyPeter Geisler, Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, 93042 Regensburg, GermanyBerthold Langguth, Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstraße 84, 93042 Regensburg, GermanyPeter Eichhammer, Department...