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Tiotropium versus placebo for chronic obstructive pulmonary disease.

CONCLUSIONS: This review shows that tiotropium treatment was associated with a significant improvement in patients' quality of life and it reduced the risk of exacerbations, with a number needed to treat to benefit (NNTB) of 16 to prevent one exacerbation. Tiotropium also reduced exacerbations leading to hospitalisation but no significant difference was found for hospitalisation of any cause or mortality. Thus, tiotropium appears to be a reasonable choice for the management of patients with stable COPD, as proposed in guidelines. The review however, shows that tiotropium delivered via the Respimat soft mist inhaler was associated with a significantly increased risk of mortality compared with placebo, which calls for caution with this device whilst awaiting the results of an ongoing head-to...

Influence of obesity on nocturnal oxygen saturation in young children

Conclusion: In young children, higher body weight is associated with a decrease in nocturnal oxygen saturation. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00431-012-1806-5Authors Marjolein J. Korndewal, Department of Pediatrics, Gelre Hospitals, Postbus 9014, 7300 DS Apeldoorn, The NetherlandsWillem M. H. Geurts van Kessel, Department of Pediatrics, Gelre Hospitals, Postbus 9014, 7300 DS Apeldoorn, The NetherlandsLia G. Jak, Primary Youth Health Care Center Vérian, Apeldoorn, The NetherlandsCuno S. P. M. Uiterwaal, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The NetherlandsMechelien H. Rövekamp, Department of Pediatrics, Gelre Hospitals, Postbus 9014, 7300 DS Apeldoorn, The NetherlandsCornelis K. v...

Long-term oxygen therapy

New insights and perspectivesLong-term oxygen therapy (LTOT) usually represents the final step in the management of severe chronic respiratory diseases: a large proportion of patients suffering from these conditions is involved and the corresponding impact for the Health Institutions and the Society is dramatically increasing. Although LTOT is well known and widely used since long ago in most modern countries, it still ... (Source: Springer Medicine titles)

Influence of air pollutants on allergic sensitization: the paradox of increased allergies and decreased resistance to infection.

Authors: Gilmour MI Abstract Air pollution has long been associated with health risks such as increased susceptibility to respiratory infections and potentiation of asthmatic-type responses. Experimental evidence in rodents indicates that air pollutants including diesel exhaust particles (DEPs), gases, and metals cause lung injury, inflammation, reduce aspects of host defense, and may potentiate allergic airway responses. Here we present evidence that diesel exhaust particles delivered by inhalation or aspiration can exacerbate allergic lung disease depending on the material's chemical properties. Genomic analysis of mouse lungs following instillation or inhalation of DEPs shows an alteration spectrum of pathways associated with immune signaling, cell metabolism, and oxidative stre...

[Changes in classiffication of primary lung adenocarcinoma according to reccomendations of International Association for the Study of Lung Cancer/ /American Thoracic Society/European Respiratory Society].

Authors: Szołkowska M, Langfort R, Szczepulska-Wójcik E, Maksymiuk B PMID: 22370986 [PubMed - indexed for MEDLINE] (Source: Pneumonologia i Alergologia Polska)

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