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Racial Differences in Allergic Sensitization: Recent Findings and Future Directions.

Racial Differences in Allergic Sensitization: Recent Findings and Future Directions.

Curr Allergy Asthma Rep. 2013 Feb 26;

Authors: Wegienka G, Johnson CC, Zoratti E, Havstad S

Abstract
Racial disparities are present in many facets of health and disease. Allergy and asthma are no exceptions. Secondary results from cross-sectional and cohort studies have provided information on the scope of racial disparities in allergic sensitization in the United States. African American/Black individuals tend to be sensitized more frequently than White individuals. Little is known about rates in other race groups. Genetics are unlikely to be the sole or major cause of the observed differences. Home dust allergen and endotoxin levels cannot explain the differences. Studies that have been designed to specifically address the sources of these racial disparities are needed. A "Multilevel Framework" that considers the roles of the individual, family and community presents an excellent approach to guide design of future studies of the causes of these disparities. Understanding the causes of the disparities could lead to interventions that would improve the health of all individuals.

PMID: 23435599 [PubMed - as supplied by publisher]

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Bronchiectasis Exacerbation Study on azithromycin and amoxycillin-clavulanate for respiratory exacerbations in children (BEST-2): study protocol for a randomized controlled trial

DiscussionCurrently, there are no published randomized controlled trials (RCT) to underpin effective, evidence-based management of acute respiratory exacerbations in children with non-CF bronchiectasis. To help address this information gap, we are conducting two RCTs. The first (bronchiectasis exacerbation study; BEST-1) evaluates the efficacy of azithromycin and amoxycillin-clavulanate compared with placebo, and the second RCT (BEST-2), described here, is designed to determine if azithromycin is non-inferior to amoxycillin-clavulanate in achieving symptom resolution by day 21 of treatment in children with acute respiratory exacerbations.Trial registration: Australia and New Zealand Clinical Trials Register (ANZCTR) number ACTRN12612000010897. http://www.anzctr.org.au/trial_view.aspx?id=34...

Exhaled nitric oxide shows promise as childhood asthma predictor

High levels of exhaled nitric oxide in infancy predict asthma development in later childhood, show study findings. (Source: MedWire News - Respiratory)

Non-tuberculous mycobacterial disease risk increased in COPD

Chronic respiratory disease is a significant risk factor for non-tuberculous mycobacterial pulmonary disease, results from a French study show. (Source: MedWire News - Respiratory)

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