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Preserved function and reduced angiogenesis potential of the quadriceps in patients with mild COPD

Conclusions: The quadriceps muscle function was preserved in mild COPD although a reduced potential for angiogenesis was found. The reduced level of daily activities and evidence of systemic inflammation in these individuals suggest that these factors precede the development of overt limb muscle dysfunction in COPD. (Source: Respiratory Research)

[Immunopathogenesis of idiopathic pulmonary fibrosis].

Authors: Demkow U Abstract The paper presents the state of the art in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Both, etiology and pathogenesis of IPF are unclear. The key elements in the pathogenesis of the disease are epithelial destruction and dysregulation of the phenotype of lung fibroblasts. Currently accepted hypothesis claims that IPF is not related to underlying inflammatory state but it is rather a result of pathological interaction between pulmonary epithelium and mesenchyme followed by disturbed healing of damaged alveolar epithelial cells. The function of lung progenitor cells residing in distant lung structures is also impaired. Some scientists claim that genetic defect causes fast shortening of telomeres reducing lung properties of regeneration. Accord...

[Physiotherapy in patients after lung parenchyma resection].

Authors: Wnuk D, Hansdorfer-Korzon R, Zuralska-Wnuk J, Chwirot P, Barna M Abstract Lung parenchyma resection is the treatment of choice for early-stage lung cancer. The surgery involves the loss of respiratory surface and consequently leads to reduction in exercise capacity. Proper rehabilitation is essential for restoring the function and good performance of the respiratory system. Rehabilitation should be an integral part of surgical treatment. It should be implemented early and maintained until full restoration of function and fitness. The paper discusses the physiotherapeutic procedure in patients after lung parenchyma resection. Under current guidelines, the recommended physiotherapeutic approach has been described as a multi-stage process. A preoperative exercise program can ...

Levels of physical activity and predictors of mortality in COPD

CONCLUSIONS: In our sample, the cut-off of 4,580 steps/day was not sensitive enough to identify differences between the groups when compared with the predictors of mortality. The IPAQ, short version score correlated with steps/day. OBJETIVO: Comparar a pontuação do índice Body mass index, airway Obstruction, Dyspnea, and Exercise capacity (BODE) e seus componentes individuais em pacientes com DPOC com grave inatividade física ou não, assim como correlacionar o número de passos diários com pontuações de questionários de atividade física, idade, índice BODE e seus componentes. MÉTODOS: Foram incluídos 30 pacientes, os quais foram avaliados quanto a sua composição corporal, função pulmonar (VEF1), percepção de dispneia (escala modified Medical Research Council) e capacida...

EAACI position statement on asthma exacerbations and severe asthma.

Related Articles

Asthma exacerbations and severe asthma are linked with high morbidity, significant mortality and high treatment costs. Recurrent asthma exacerbations cause a decline in lung function and, in childhood, are linked to development of persistent asthma.

This position paper, from the European Academy of Allergy and Clinical Immunology, highlights the shortcomings of current treatment guidelines for patients suffering from frequent asthma exacerbations and those with difficult-to-treat asthma and severe treatment-resistant asthma.

It reviews current evidence that supports a call for increased awareness of

  • the seriousness of asthma exacerbations
  • and the need for novel treatment strategies in specific forms of severe treatment-resistant asthma.

There is strong evidence linking asthma exacerbations with viral airway infection and underlying deficiencies in innate immunity and evidence of a synergism between viral infection and allergic mechanisms in increasing risk of exacerbations. Nonadherence to prescribed medication has been identified as a common clinical problem amongst adults and children with difficult-to-control asthma. Appropriate diagnosis, assessment of adherence and other potentially modifiable factors (such as passive or active smoking, ongoing allergen exposure, psychosocial factors) have to be a priority in clinical assessment of all patients with difficult-to-control asthma.

Further studies with improved designs and new diagnostic tools are needed to properly characterize (i) the pathophysiology and risk of asthma exacerbations, and (ii) the clinical and pathophysiological heterogeneity of severe asthma.

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