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Common antibiotic linked to 'tiny' rise in heart deaths

Conclusion The conclusion that the risk of cardiac death during the use of clarithromycin is 76% higher than that for penicillin V was based on a small number of cardiac deaths. In fact, it occurred during 0.01% of prescriptions of clarithromycin, compared with 0.005% during prescriptions for penicillin V. A death rate just a bit higher than a very small death rate is still very small. This means that from an individual point of view, the risk of cardiac death from taking either antibiotic is minimal. This study does not prove clarithromycin caused any cardiac deaths. It only showed a very small increased risk of cardiac death in the seven days after the prescription was collected in a select group of people. This did not include: antibiotic use in hospitals people with serious ...

Review of clinical treatment of bronchiolitis in infants reveals over-reliance on one test

The importance of physicians using all available clinical assessment tools when considering how to treat patients is the focus of a new article. The study examined how pediatric emergency medicine physicians treat a respiratory tract infection called bronchiolitis in infants, and how they incorporate factors such as respiratory exam, imaging tools and blood tests when deciding on treatment. (Source: ScienceDaily Headlines)

The role of non‐invasive biomarkers in detecting acute respiratory effects of traffic‐related air pollution

In conclusion, this survey of current literature displays the complexity of this research field, highlights the significance of short‐term studies on traffic pollution and gives important tips when planning studies to detect acute respiratory effects of air pollution in a non‐invasive way. (Source: Clinical and Experimental Allergy)

The Allergies, Immunotherapy, and RhinoconjunctivitiS (AIRS) survey: provider practices and beliefs about allergen immunotherapy.

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The Allergies, Immunotherapy, and RhinoconjunctivitiS (AIRS) survey: provider practices and beliefs about allergen immunotherapy.

Int Forum Allergy Rhinol. 2014 Aug 14;

Authors: Leatherman B, Skoner DP, Hadley JA, Walstein N, Blaiss MS, Dykewicz MS, Craig T, Smith N, Allen-Ramey F

Abstract
BACKGROUND: The practices and beliefs of the provider specialties that treat allergic rhinoconjunctivitis (ARC) with allergen immunotherapy (AIT) may vary.
METHODS: A telephone survey of 500 randomly selected health care practitioners in 7 specialties, conducted in 2012.
RESULTS: AIT was provided as a subcutaneous injection (SCIT) by 91% of allergist/immunologists, 54% of otolaryngologists, and 18% to 24% of other specialties. Otolaryngologists were the most frequent providers of sublingual drops of AIT (SLIT; 33%), compared to 2% to 10% of other specialties. AIT was recommended for adults with allergic rhinoconjunctivitis by 100% of allergist/immunologists vs 62% to 84% of the other specialties (p < 0.001). The primary reason for recommending AIT for adults (52%) or children (46%) was that other therapies did not work. Between 48% (nurse practitioners/physician assistants) and 93% (allergist/immunologists) of practitioners always or often decreased symptomatic medications over the course of AIT treatment. Most practitioners in all specialties (82-100%) thought that AIT was appropriate for patients with severe allergy symptoms. Significantly more allergist/immunologists and otolaryngologists than other specialists thought AIT was appropriate for mild allergy symptoms (p < 0.001 and p = 0.004, respectively, vs other specialties). Significantly more allergist/immunologists than other specialists thought that AIT was more effective than symptomatic medications (p < 0.001), could reduce the further development of allergies (p = 0.03), and could prevent the development of asthma.
CONCLUSION: SCIT was more frequently provided than SLIT by all the specialties. Otolaryngologists were the most likely to offer SLIT, while very few allergist/immunologists offered SLIT. Allergist/immunologists differed from other specialties in some beliefs about the effectiveness of AIT.

PMID: 25123933 [PubMed - as supplied by publisher]

The association of asthma and atrial fibrillation - A nationwide population-based nested case-control study.

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The association of asthma and atrial fibrillation - A nationwide population-based nested case-control study.

Int J Cardiol. 2014 Aug 1;

Authors: Chan WL, Yang KP, Chao TF, Huang CC, Huang PH, Chen YC, Chen TJ, Lin SJ, Chen JW, Leu HB

Abstract
BACKGROUND: Asthma and atrial fibrillation (AF) have been reported to be related to an increased risk of cardiovascular events. However, the relationship between asthma and AF has not been fully elucidated. The purpose of this study was to examine the association between asthma and AF risk.
METHODS: We conducted a population-based nested case-control study including a total of 7439 newly-diagnosed adult patients with AF and 10,075 age-, gender-, comorbidity-, and cohort entry date-matched subjects without AF from the Taiwan National Health Insurance database. Exposure to asthma as well as medications including bronchodilators and corticosteroid before the index date was evaluated to investigate the association between AF and asthma as well as concurrent medications.
RESULTS: AF patients were 1.2 times (adjusted OR 1.2, 95% CI 1.109-1.298) more likely to be associated with a future occurrence of asthma independent of comorbidities and treatment with corticosteroids and bronchodilator. In addition, the risks of new-onset AF were significantly higher among current users of inhaled corticosteroid, oral corticosteroids, and bronchodilators. Newly users (within 6months) have the highest risk (inhaled corticosteroid: OR, 2.13; 95% CI, 1.226-3.701, P=0.007; oral corticosteroid: OR, 1.932; 95% CI, 1.66-2.25, P<0.001; non-steroid bronchodilator: OR, 2.849; 95% CI, 2.48-3.273, P<0.001). A graded association with AF risk was also observed among subjects treated with corticosteroid (inhaled and systemic administration) and bronchodilators. New users (within 6months) of these medications had the highest risk of AF (ICS: OR, 2.13; 95% CI, 1.226-3.701, P=0.007; oral corticosteroid: OR, 1.932; 95% CI, 1.66-2.25, P<0.001; non-steroid bronchodilator: OR, 2.849; 95% CI, 2.48-3.273, P<0.001). A graded association with AF risk was also observed among subjects treated with ICS or bronchodilator.
CONCLUSIONS: Asthma was associated with an increased risk of developing future AF.

PMID: 25127961 [PubMed - as supplied by publisher]

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