The aim of this study was to describe the impact of COPD on health status in the Burden of Obstructive Lung Disease (BOLD) populations.We conducted a cross-sectional, general population-based survey in 11,985 subjects from 17 countries.

We measured spirometric lung function and assessed health status using the short form 12 questionnaire (SF 12). The physical (PCS) and mental health (MCS) component scores were calculated.

Subjects with COPD (post-bronchodilator FEV1/FVC<0.70, n=2269) had lower PCS (44±10 vs. 48±10 units, p<0.0001) and MCS (51±10 vs. 52±10 units, p=0.005) than subjects without COPD. The effect of reported heart disease, hypertension, and diabetes on PCS (-3 to -4 units) was considerably less than the effect of COPD GOLD grade 3 (-8 units) or 4 (-11 units). Dyspnoea was the most important determinant of a low PCS and MCS. In addition, lower FEV1, chronic cough, chronic phlegm and the presence of comorbidities were all associated with a lower PCS.COPD is associated with poorer health status but the effect is stronger on the physical than the mental aspects of health status.

Severe COPD has a greater negative impact on health status than self-reported cardiovascular disease and diabetes.