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Aim: To evaluate health-related-quality-of-life and the asthma control test in children with problematic severe asthma and controlled asthma, and to identify whether clinical characteristics show correlations with these measurements.
Methods: This multicentre cross-sectional study included 93 children in total, 54 with problematic severe asthma and 39 age-matched with controlled asthma. Subjects completed the Paediatric Asthma Quality-of-Life Questionnaire as well as a standardised health questionnaire and the asthma control test. Objective measurements of exhaled nitric oxide, specific sensitisation, pulmonary function and bronchial hyperresponsiveness to methacholine were also performed.
Results: Health-related-quality-of-life was reduced in children with problematic severe asthma (5.4 versus 6.7, p=<0.001), particularly for girls (5.1 versus 5.6 for boys, p=0.02), and asthma control test scores were also lower (17 versus 23, p=<0.001) compared to subjects with controlled asthma. A health-related-quality-of-life score < 6.2 discriminated problematic severe asthma from controlled asthma with 85% sensitivity and 97% specificity, as did the asthma control test score < 20 (79% sensitivity and 94% specificity). Objective measures and other clinical characteristics were weakly associated with health-related-quality-of-life or asthma control test score.
Conclusion: Subjective measurements of health-related-quality-of-life and asthma control are both equally useful in differentiating children with problematic severe asthma from those with controlled asthma.
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Acta Paediatr. 2011 May 19;
Authors: Nordlund B, Konradsen JR, Pedroletti C, Kull I, Hedlin G
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