In this report we discuss two cases of patients with Pulmonary Arterial Hypertension. Both patients were evaluated and were recommended therapy according to current acceptable guidelines. Despite these recommendations, each patient sought on their own accord, additional therapy in the form of stem cell therapy. They subsequently received an infusion of stem cells into their pulmonary circulation.

Objective and subjective measures were followed prior to and following infusion. After a review of each case we briefly discuss the decisions a physician must face when a patient seeks therapies not proven safe or effective by a governing authority.